#TransMed COSI session Francesco Iorio (@Francesco_i0ri0) with prioritizing cancer therapeutic target through Francesco_i0ri0 screens and multiomics data integration #ISMBECCB

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency datasets biorxiv.org/content/10.110…

Package available online.

Today, we released the Canadian #CancerStats 2019 report. It shows survival for blood cancers has increased more than any other cancer in 20 years! Cancer survival overall has ⬆️ from 55% to 63% – up 8 percentage points compared to 16-19 for blood cancers. Find out more.

It's sobering that in 2019, some people try to interpret protein-mRNA correlations without taking into account the reliability of the measurements. The first hypothesis to consider should be that poor correlations are due to poor measurements.

# of papers using single cell techniques: 10,000 # of papers describing novel bioinformatics technique on single cell data: 1,000,000,000,000 (approximate numbers)

#postdocappreciationweek wrapped up at University Health Network with a social event for #postdocs. The UHN Research EVP Brad Wouters 🇨🇦 came by to chat and thank all the amazing postdocs who make University Health Network one of the best research institutes in #canada and the world! 1/3

A big thank you to Tracy Lackraj Tracy Lackraj, Amanda Ali Dr. Amanda Ali), Razieh Rabani, Arvind Singh Mer, Reza Faieghi @Reza___F, Sina Mehdizadeh, Anusha Ratneswaran and Sofija Spasojevic Sofija Spasojevic who organized #postdocappreciationweek for UHN Research. 2/3

Does somebody know public datasets on which #neoantigen predictors can be benchmarked (database of neoantigens known to mediate cancer destruction and negative controls from the same tumors)? #cancer #tumor #immunotherapy

Critical effort to establish standards in PDX drug dosing experiment and analysis - Only adherence to such standards will ensure reproducibility and dataset interoperability - Standards in PDX Experiments and Analysis biorxiv.org/content/10.110… The Jackson Laboratory @jeffgenome EurOPDX

We've got a trifecta of new #TRACERx papers this Tuesday! Intratumoral transcriptional heterogeneity can now be overcome with an approach for the identification of clonal expression biomarkers | go.nature.com/35p4zLk | #lungcancer Charles Swanton Nicholas McGranahan

Single-nucleus RNA and ATAC-seq from the same (!) cell at scale Nature Biotechnology. nature.com/articles/s4158…

🇨🇳 : please fill in the impact factor of the journal for every paper you publish. 🇵🇹 : hold my beer

(1)We’re excited to share a preprint of our new paper "Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity" biorxiv.org/content/10.110… co-led by Gabriela Kinker and Alissa Greenwald.

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors cell.com/cancer-cell/fu…

And 🇨🇦... CIHR Budget = $1Billion CAN GDP = $1.7 Trillion+ Share of GDP = 0.06%.... Underinvesting only our future.

Our #MAQC20 meeting website is launched! Give it a click learn more about the meeting agenda or venue. maqc2020.org/maqc-2020-meet…

I really thought the t-SNE patent was the worst I'd see...I was wrong. x.com/lpachter/statu…

(1/9) This correspondence in The Lancet bothers me in both my researcher and patient hats, starting with the opening sentence, "Analysing personal data is a privilege requiring researchers to safeguard data and to use data wisely." thelancet.com/journals/lance…

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