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Well-conducted and independent trial. Huge amount of work over many years for the authors and a really clinically important result. Quetiapine better for augmentation in treatment resistant depression.

SSRI & Placebo Randomized trial: all participants receive Lexapro for social anxiety. Half are told it's an active placebo, half are told it's a medication. Results show a 3.6 times higher response rate in those told it's a medication. Conclusion "effects of escitalopram

Psychiatry will be a completely different field in the next 10 years.

1/ Malignant narcissism “Malignant narcissism is a variant of narcissistic personality that has gained public attention in recent years. It is, in fact, the intersection of narcissistic personality and antisocial-psychopathic personality, blending the characteristics of both.

Psychiatrists should talk to you about your physical health. Non-psychiatrists should talk to you about your mental health. It's not helpful to talk about mental and physical health in isolation.

Psychiatry could learn a lot by reconnecting with philosophy

Nicolas Badre Major phenomenological differences between suicides observed in major mood illnesses and those in personality disorders. In the latter, they are almost always impulsive, often accidental, triggered by an interpersonal event, and carry a hidden (or not-so-hidden) message.

🧵When Physical Pain Meets Psychiatry 🚨 1/15 Pain doesn’t just arise from the body -it’s constructed by the brain. The circuits that mediate emotional and physical pain overlap. That’s why in psychiatry, we don’t just treat pain as a symptom -we treat it as a signal. Here’s

Just out! The BMA loses judicial review claim against GMC. The BMA had sought declarations that 1) the application of Good Medical Practice to Physician Associates and Anaesthesia Associates is lawful and 2) use of the term ‘medical professionals’ by the GMC when referring to

Flicking through my The BMJ and came across this explanation of #overdiagnosis by Suzanne O’Sullivan. Makes a lot of sense - diagnosis is only useful if it helps explain or direct treatment. Sometimes the same diagnosis may be helpful for some but not others.

What is going on with #ADHD? My take (inspired mostly by my Tufts colleague, Nassir Ghaemi): To understand this problem, one needs to know a little bit about history and how the psychiatric classification system works. Many mental disorders present with problems with attention,

Powerful article. What has happened to UK Psychiatry and what should/can the RCPsych do about it? newstatesman.com/politics/healt…

ADHD, Bipolar Disorder, Major Depressive Disorder, and other psychiatric diagnoses are not the cause of your symptoms— they are simply labels to describe the symptoms you are having. It’s important to ask what’s causing them. newsletter.brainenergy.com/mental-health-…

Yo momma

This time-lapse captures 17h of axonal growth from a chick dorsal root ganglion explant, seen through the actin cytoskeleton using live imaging. I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours!😉 #neuroscience

Barriers to use of clozapine to treat psychosis in Parkinson’s.

Another vote for clozapine

1/ Highlights: About 7 out of 10 patients who get “evidence-based therapy” for depression rare still depressed after treatment Of the 3 that get well, about half would have gotten well without treatment No significant differences between types of therapy (the “dodo bird

Never choose “type of therapy” Choose the therapist. Everything depends on the expertise of the therapist, and the fit If therapist is truly expert and you need something they don’t do, they’ll offer a referral. If not, it doesn’t matter what “type of therapy” they claim to do

A phenomenal study that deserves careful reading. 🔥🔥indeed