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The most expensive words in IBD: "Let's wait and see" This morning's blog post is getting incredible engagement - seems I struck a nerve talking about our need to treat Crohn's disease early and aggressively. The PROFILE trial data speaks for itself: • Top-down therapy: 79%

In the #RedJournal:   HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease Adler, et al.   📕 bit.ly/4mkeaKL Jeremy Adler, MD, MSc Athos Bousvaros

Modern life is starving our microbiome of diversity Ancient genes—evolved to fight infections—now mis-fire in today’s environment, tipping the balance toward IBD. Genes × Microbiota × Environment: the triangle of clues

For all my hepatologists out there, am I missing something? Why won’t GLP1a just crush Rezdiffra when FDA approves it for MASH? There must be a reason why Novo Nordisk paid for a giant DDW Booth and was selling no drug? Just letting people know about MASH.

Injectable semaglutide reduces the risk of major adverse cardiovascular events in persons with type 2 diabetes and high cardiovascular risk. Research findings from the SOUL trial with oral semaglutide are summarized in a new Quick Take video. nej.md/3Ze59cr

In New Methods, Ogura et al detail "Technical feasibility of EUS-guided liver abscess drainage for the right hepatic lobe using a novel metal stent as first-line treatment (with video)." giejournal.org/article/S0016-… #GITwitter

New online! The gut microbiome connects nutrition and human health bit.ly/459iOVN

Diet shapes the gut #microbiome, which is at the center of health and disease #MedTwitter #GITwitter nature.com/articles/s4157…

In a UK study of 5.16M pregnancies (2000–2021), autoimmune disease in pregnancy rose from 3.5% to 4.7%. IBD was the 2nd most prevalent autoimmune condition after psoriasis. Autoimmune risk was higher in ex-smokers, multiparas, and women with mental or metabolic comorbidities.

Original Article: Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (ESSENCE) nej.md/3EVFAFM Editorial: Semaglutide for Metabolic Dysfunction–Associated Steatohepatitis nej.md/3ZJSmOQ #Endocrinology #Gastroenterology

Submucosal Lifting Agents 💉 Saline lifts short, cheap 🟦 Gel lifts last longer ⚠️ Can leave tattoo artifact 🔬 Mimics mucin or cancer ⏳ Longer lift = better EMR 📸 Document lift agent used 📄 FDA cleared ≠ inert Summary of lifting agents below 👇 🔗 cghjournal.org/action/showPdf…

➡️ Disease Clearance in #Ulcerative #Colitis What is the definition of remission in Ulcerative Colitis? Read more in UEG Journal: 👉 bit.ly/3SCLwa9

Azathioprine (AZA) Pearls - Additional pearls: - Non-melanoma skin cancers are increased, especially in tropical countries - If the whte blood cell count falls below 3000/μL, platelets drop below 120000/μL, or liver tests increases more than half of the normal upper limit, AZA

𝐂𝐑𝐈𝐒𝐏𝐑-𝐂𝐚𝐬𝟗 is a process in which clustered regularly interspaced short palindromic repeats (CRISPR) — small remnants of viral DNA from previous viral infection that are embedded in bacterial DNA — generate guide RNAs, which are used together with a DNA-cutting enzyme

GLORY-1 trial: Obesity and overweight are well-recognized risk factors for a range of diseases. Research evaluating the efficacy and safety of mazdutide in long-term weight management is summarized in a short video. nej.md/4l6zMZP

Introducing the FACILE Classification for IBD Lesions: Developed by international experts Fully validated system Optical diagnosis of IBD-associated neoplasia

What happens to our patients after faecal diversion with Crohn’s disease Check out our latest paper here: onlinelibrary.wiley.com/doi/10.1111/17… Thanks to co-authors John Ding MD PhD #imogenhartley

💉 What advanced therapy is most efficacious in UC proctitis? ✅ Vedolizumab, which led to ~70% steroid free clinical remission in a single center study of pts with UC proctitis Rahul S. Dalal, MD, MPH Jessica R Allegretti doi.org/10.1093/ibd/iz…