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Very excited to share our latest preprint on lineage effects in neural organoids following GC exposure. biorxiv.org/content/10.110… @silvianeurompi Fabian Theis Cristiana Cruceanu Binder Lab Our results suggest converg. mechanisms for environmental and genetic risk for psych. disease. (1/N)

Indeed, the Inh. to Ex. Neuron marker expression ratio increased after GC eposure. We confirmed an increase in GAD1 expression after GC exposure in an IHC validation. (4/N)

We identified 15 TFs that had an aligned DE and lineage driving effect for Inh. Neurons. PBX3 was the most specific for the Inh. Neuron lin. of the TFs regulated alongside their know targets. Multimodal GRN inference (Pando) showed strong DE signal downstream of PBX3 (red). (5/N)

Indeed, what a well-deserved recognition for one of my favorite scientists!

I am pleased to share our new paper on a bystander neuroprotective mechanism employed by the spinal cord after injury. I want to thank all the colleagues who contributed: nature.com/articles/s4146…

Congratulations to Cristiana Cruceanu and Robert McCutcheon as the winners of the 2024 ECNP Rising Star Award. 🏆 The award celebrates Early Career Scientists whose research has the potential to advance the science of the brain. Read more: ecnp.eu/rising-star-aw… #ECNP #neuroscience

Excited to be in Vienna for my first #FENS2024 FENS ! Looking forward to the amazing science. And to hopefully meet other stress researchers at our symposium on Friday morning.

Fantastic preprint out from the great lab of Natalie Matosin led by the very talented Dominic Kaul. Congrats to all the authors for this beautiful work. A great read for anyone interested in glial biology and the role these fascinating cells play in stress.

🚨Open #postdoc position! Join me and Johan Lundberg @lundberglab.bsky.social at Karolinska Institutet @StratNeuro on a exciting collaborative project to study the molecular mechanisms behind the antidepressant effects of psychedelic compounds. Apply here: ki.varbi.com/what:job/jobID… Please RT 🙌

Don’t miss this great opportunity if you are looking for ambitious and innovative research in a fun, supportive and collaborative environment. Really cannot go wrong with this postdoc. Strongly recommend! And living in beautiful Stockholm is not bad either.

Really looking forward to this!

Apply now to join us as a PhD student! 🥳

🎉Congratulations again to all ECNP Award winners! 🏆👏 Your groundbreaking work in applied and translational #neuroscience is truly shaping the future of #MentalHealth research.🌍🔬 #ECNP #ScientificExcellence #ECNP2024

Super excited to share our Human Neural Organoid Atlas, now out in Nature! Led by ZhiSong He 何志嵩 Jonas (josch1@bsky) and myself, this resource was created from 36 scRNA-seq datasets—totalling over 1.7 million cells! 🔬✨ 🦋🧵-> bsky.app/profile/le-and… nature.com/articles/s4158…

🧠Using #organoids (pictured below), Leander, Binder Lab, Cristiana Cruceanu's lab and Fabian Theis' lab found that #glucocorticoids, often prescribed before premature delivery, alter the neuronal balance in the developing brain. 📰Read more: psych.mpg.de/2943345/news_p…

So excited to share the work of the fantastic Katarzyna Anna Dudek, 1st PhD student of my lab 🧠, out in Nature Neuroscience 🥂🥳 Cheers to the team, thanks to our precious collaborators and support from Brain Canada CIHR FRQ - secteur Santé Université Laval CERVO nature.com/articles/s4159…