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Very gratifying to see WRN inhibitors progressing to the clinic. Looking forward to the results It was only in 2019 when we and others published the discovery of WRN as a target in MSI-H tumors doi.org/10.1038/s41586… The Cancer Dependency Map

Genetic dependencies associated with transcription factor activities in human cancer cell lines: Cell Reports cell.com/cell-reports/f…

Great use of The Cancer Dependency Map data Congratulations to all involved

🎉New DepMap data and tools available on the portal! We’re excited to release new Omics and CRISPR data to the DepMap portal, as well as a new portal tool, Data Explorer 2.0, and a new DataHub where you can learn more about DepMap’s data structure and how to map data files.

Impressive resource & dataset for those researching #Cholangiocarcinoma & other #BileDuct cancers. Preprint from Francisca Vazquez Gaddy Getz & Nabeel Bardeesy Mass General Cancer Center Broad Institute. Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and

Happy to share our lab’s latest work led by Hannah Weinstein and Kevin Hu about the endlessly interesting ribosomal protein RPL22 and its role in splicing and cancer. Thanks to all of our collaborators incl Hani Goodarzi Francisca Vazquez Mahmoud Ghandi cell.com/cell-reports/f…

New paper by Pedro Latorre Muro published in Cell! We combined thermoregulatory physiology, structural and computational approaches to determine the mechanisms of electron transfer and structural basis of respiratory complex adaptation to cold temperatures.

How do you use the DepMap Portal? 💻 As we enter the final year of our grant, we need your insights! Take this quick 2-question survey to help us understand what you like and what you'd like to see in the future. Your feedback is invaluable!  broad.io/dmp2024

Dear #DepMap portal users, we need your support for our NIH grant application funding the DepMap portal. If you like the portal, please consider answering this two-question survey so we can learn how you use it.

A review on the Cancer DepMap in Nature Reviews Cancer An invaluable publicly available dataset (containing both profiling and FUNCTIONAL data) from Broad Institute. The present and future of the Cancer Dependency Map nature.com/articles/s4156… Francisca Vazquez

New DepMap Release! ⭐ 35 CRISPR screens ⭐ NEW data from our Pediatric Dependencies Accelerator Program (learn more at PedDep.org) ⭐ First 281 WES -> WGS ⭐ New Resources page 📣 DepMap is now on dbGaP (phs003444.v1.p1) Read our release notes for more info!

DepMap keeps growing—and so does the portal! To help navigate the portal, new in 24Q4 we’ve launched a new resource page 🚀! Check it out and share your feedback. depmap.org/portal/resourc…

We are hiring! After the publication of our last paper, our lab has openings for #postdoc fellows in projects looking at the interactions between tumor metabolism and immunology. Direct inquiries to [email protected]. Please RT! (1/2)

📢 Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute) Highly recommended! Register here grc.org/synthetic-leth…

Synthetic lethality of mRNA quality control complexes in cancer nature Francisca Vazquez nature.com/articles/s4158… nature.com/articles/s4158… nature.com/articles/d4158…

#ResearchWatch: Disruption of the SKI Complex Confers Dependency on PELO in Cancer brnw.ch/21wQXPo A summary of two complementary studies by Patricia Borck, Edmond Chan, Francisca Vazquez, Vivian Prindle, Adam Richardson, Kimberly Sher, and Joshua Plotnik. Broad Institute

Excited to share our comprehensive cell line atlas for biliary tract cancer (BTC) in collab with Dr. Nabeel Bardeesy Mass General Cancer Center & Francisca Vazquez, and led by Vindhya Vijay & Negin Karisani! doi.org/10.1158/2159-8… The Cancer Dependency Map Cancer Discovery Also see: massgeneralbrigham.org/en/about/newsr…