🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Our newest paper is out today in PNAS! Small-molecule disruption of androgen receptor–dependent chromatin clusters pnas.org/doi/10.1073/pn…

Subgroup analysis of our 1L SOC #EV302 for mUC by Shilpa Gupta #ASCO25 Of responders: ➡️1/2 maintain response @ 2 yrs (74% for CR) ➡️76% alive at 2 yrs (94% w/ CR) 🌀median 12 cycles EV/P, dose mod in 59-69%, ~60% w/ grade 3 toxicity - neuropathy & derm - can we de-escalate?

🌞 Good morning, #ASCO25! Before diving into today’s sessions, let’s recap the groundbreaking studies from yesterday’s plenary and breast cancer presentations. Here’s a quick summary of the highlights:

Great job by Ilana E. presenting ctDNA data from our combined Dana-Farber Lank Center for Genitourinary Oncology Mass General Cancer Center Brigham and Women’s Radiation Oncology cohort of patients with MIBC treated with TMT! Post-treatment ctDNA status is highly prognostic in the TMT setting.

#ASCO25 Was humbled to see a patient approach me on the heels of our presentation yesterday & sharing his experience of achieving CR with EV-P & maintaining it despite on a break from EV for neuropathy. He thanked us for validating his personal experience & providing reassurance

Grateful for the opportunity to present our CLONEVO investigator-initiated trial (IIT) in bladder cancer at ASCO #ASCO2025. Here are some lessons I learned along the way: Investigator-initiated trials (IITs) are essential. IITs are clinical trials independently designed and led

🚨 Wow! #ASCO25 ASCO was absolutely massive! 10 NEJM papers published simultaneously 👉 all practice-changing studies ! 🔬✨🧵 See below for these studies 👇@oncoalert

Targeting lineage plasticity in #ProstateCancer with EZH2 inhibitor mevrometostat. Michael Schweizer Fred Hutch Cancer Center sits down with Oliver Sartor, MD Mayo Clinic diving into #mevrometostat—an #EZH2 inhibitor tackling lineage plasticity in #mCRPC. Adding it to enzalutamide slashed

First paper out from my lab! 🎉 Thrilled to share our work on molecular profiling of Ta low-grade bladder cancer, published in European Urology Oncology: 🔗sciencedirect.com/science/articl… Many thanks to Joep J. de Jong, Peter Black, and Lars Dyrskjøt! #bladdercancer #genomics #NMIBC #uroonc

Thanks Sophia Kamran, MD & Constantinos Zamboglou for this invitation to highlight keypoints and thoughts about ADT and Post-op RT. sciencedirect.com/science/articl… ✨✨✨✨✨✨✨✨✨✨

Big shout out to rising M4 and MSTP at Case Western Reserve University student Eshan King - whose paper came out in Science Advances connecting the fields of PK-PD and evolutionary modeling using fitness seascapes. #mathevo #mathonco Michael Baym CWRU School of Medicine Cleveland Clinic Lerner Research Institute science.org/doi/10.1126/sc…

Always impressed with quality work of my colleagues Fred Hutch Cancer Center & external colleagues! This study is about heterogeneity in lethal #ProstateCancer led by Michael Haffner & team! jci.org/articles/view/… Hsieh Lab Gavin Ha Prostate Cancer Foundation Neeraj Agarwal, MD, FASCO Tian Zhang, MD, MHS UroToday.com OncoAlert

Thanks Dr. Jacob Scott Jake Scott for visiting Seattle Fred Hutch Cancer Center University of Washington Radiation Oncology! Outstanding seminar on personalized radiotherapy, always great to see you, my friend. Cleveland Clinic Lerner Research Institute Cleveland Clinic Ramesh Rengan

Incredibly proud of Charlie Dai who was previously a fellow in our group and just landed a Damon Runyon Cancer Research Foundation physician scientist grant! Keep an eye on him as he is a next-level thinker and poised to be leading physician-scientist in steroid-dependent cancers! Mass General Cancer Center

Congrats Zhenfei Li and his team on his story PNASNews on fine structural design of 3βHSD1 inhibitors for prostate cancer therapy! His work builds on many years of work on HSD3B1 genetics and metabolism in prostate cancer! Prostate Cancer Foundation AACR ASCO pnas.org/doi/10.1073/pn…

Amazing talk by all with efficient tour de force across GU cancers! Thanks Nick James also on @Prof-Nick-James.bsky.social Maite Bourlon Dr. Jason Efstathiou Stephanie Berg Atish Choudhury, MD PhD Terry Friedlander Ashish M. Kamat, MD, MBBS Shilpa Gupta Karima Oualla, MD,MSc Tres Uramigas Uromigos Vivek Subbiah, MD Easter Ho Panagiotis Vlachostergios Minas Economides, MD

Congratulations 🎊 to our graduating #radonc residents ⁦David Buchberger⁩ ⁦Sean Parker⁩ & ⁦ColeBillenaMD⁩ who will be heading to Radiation Oncology Associates in Manchester, ⁦TennesseeOncology⁩ in Chattanooga & ⁦Cleveland Clinic⁩ Fairview! #CleClinicCancer

More than 16 million Americans are at risk of losing their health care because Republicans in Congress are rushing to pass a bill that would cut federal funding for Medicaid and weaken the Affordable Care Act. If the House passes this bill, it will increase costs and hurt

So honored to receive this prestigious award by ECOG-ACRIN Cancer Research Group kudos to all investigators/staff who work hard to conduct trials globally! PrECOG Naomi Haas MJ Jean Hoffman-Censits Dr. Tom Lynch Nicole D. Fleming MD Amer Zeidan MBBS,MHS ‏عامر زيدان Manmeet Ahluwalia, MD, MBA, FASCO Shilpa Gupta OncoAlert Tian Zhang, MD, MHS

The Kuni Foundation has awarded a total of $7.2 million through its Discovery Grant program to eight Fred Hutch and UW Medicine researchers specializing in adult oncology. This award will support early-stage research in developing promising new treatments. bit.ly/44SrVsn