❗️Massive…Omicron Disease Severity Study just released in pre-print. Huge thanks to our South African Colleagues who must have worked through the night to complete this so soon. Some thoughts on it… [summary last two tweets]

A good study. ✅ Only reported on cases that had an outcome ✅ Controlled for age, co-morbidity, etc… ✅ Used quite solid proxy for Omicron ✅ admitted limitations - ❌low numbers, ❌no raw data on morbidity or mortality

Results 1. Once admitted to hospital, they found no difference in disease severity between Omicron and non-Omicron (mostly Delta) Covid cases. [for period Oct to end Nov 2021]

This is important for two reasons: 1. They are not simply admitting milder cases, or detecting more incidental cases 2. Admissions can now serve as a reasonably reliable measure for severity.

2. Admission rate for Omicron in South Africa was 2.5%. For context, our current admission rate in the UK for Delta is about 1.5%.

3. There was a significant reduction in the rate of admissions between the non-Omicron cases and Omicron cases from October ‘21 to end Nov ‘21. From around 13% admission rate to the 2.5%. [The authors consider this most likely due to vaccine/immunity.]

New study finds that CETP inhibitor drugs do not reduce heart disease despite increasing HDL cholesterol in part because the increase occurs in HDL subspecies that are adverse or not protective. Harvard T.H. Chan School of Public Health

Thousands of deaths could be prevented by increasing moderate to vigorous physical by just 10 minutes per day! jamanetwork.com/journals/jamai…

Pregnant women who aren’t vaccinated against #COVID19 are at greater risk for delivering stillborn babies Microscope abnormalities showed the average placenta was 77.7% destroyed meridian.allenpress.com/aplm/article/d…

New World Obesity Atlas Obesity rates likely to double by 2030 with highest rises in lower-income countries worldobesityday.org/assets/downloa…

Review article on Benefits of intermittent fasting nature.com/articles/s4157…

Study showing approximately 7 hours is the optimal sleep duration Genetic mechanisms & brain structural changes may be associated with sleep duration & cognition & mental health Will need to get to bed earlier  😴 nature.com/articles/s4358…

Whats the effect of not using social media for a week Significant improvements in well-being, depression & anxiety A randomised trial! liebertpub.com/doi/10.1089/cy…

BIG CONGRATS to our amazing boss Cathy Steele who was presented with her #Caringatitsbest Award this morning! We are all so proud of you. Thanks to @clareteeney, Matt Archer and Dr Prashanth Patel for attending also Leicester's Hospitals British Dietetic Association CN Magazine Lisa LANE

Artificial sweeteners associated with ⬆️ risk of cardiovascular disease bmj.com/content/378/bm…

Potential benefits of least 150 minutes a week 15.7% ⬇️ all cause deaths 12.3% ⬇️ cardiovascular deaths 7.1% ⬇️ cancer-related deaths bjsm.bmj.com/content/early/…

Ensure you’ve got your complimentary ticket for #SAHF2023 Conference. Book now via the link ➡️bitly.ws/UDIj This is not one to miss! Prof Kamlesh Khunti Prof. Wasim Hanif UHB Diabetes Diabetes UK Chaand Nagpaul Pratik Choudhary John Dennis Naaheed Mukadam Kamran Abbasi Muhammad Ali Karamat BAPIO

Our latest research - chemical adherence test shows ~40% non detection of CVD meds in patients attending nephrology clinics - We hope that nephrologists will become more aware of the need to diagnose non adherence as a routine kireports.org/article/S2468-…

Prash Patel from Leicester's Hospitals now on SAHF.ORG.UK on Lipid management #SAHF2023

AT A GLANCE 📸-> All the Late Breaking Clinical Trials presented at #AHA2024. Yet another phenomenal year of abundant scientific education, research, and infinite hope in cardiovascular medicine.🫀 CardioNerds Amit Goyal MD MAS Daniel Ambinder, MD Naima Maqsood Sukriti Banthiya, MD