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The Dad of the year...

A study led by VAI’s Scott Rothbart sheds light on how interwoven epigenetic layers work together to sustain cancer cell survival. Their findings reveal a potential weak spot that could be leveraged to improve treatment. vai.org/article/pinpoi…

Our latest work, led by Benjamin Jackson and Angela Montero Memorial Sloan Kettering Cancer Center demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells

Metabolism-enthusiasts at #AACR25, join us for a symposium on the relationship between diet, metabolism, and cancer cell state tomorrow (Tuesday) at 10:15 in Grand Ballroom A! Feat. Vousden Lab, Omer Yilmaz and yours truly

#Preprint alert! Kevin (Yan-Ting) Chen, a brilliant GSK Graduate School graduate student and NCI F99/K00 awardee, identifies a novel, post-transcriptional checkpoint on intratumoral T cell function: biorxiv.org/content/10.110…

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… NEJM

Studies in mice reveal that AMPK activation mediates the effects of GLP-1RAs on AD, highlighting the therapeutic potential of GLP-1RAs for the treatment of #Alzheimers disease Nature Aging nature.com/articles/s4358…

Insane

Out today from ThePerryLab, our work suggesting how exposure to high fructose in pregnant mice or developing neonates directly affects neurodevelopment. In nature nature.com/articles/s4158… Memorial Sloan Kettering Cancer Center Weill Cornell Medicine funded by NIH NIH Common Fund cc: Jay Bhattacharya, MD, PhD

IL-17 is a therapeutic target for intestinal polyposis driven by mutations in the tumor suppressor LKB1 science.org/doi/10.1126/sc… Science Advances Russell Jones

Researchers discovered that cytokine IL-17 plays a key role in polyp formation in the digestive tracts of LKB1 mutant mice. This suggests blocking IL-17 with antibodies may slow the growth of LKB1 mutant tumors. Russell Jones scim.ag/3ZEYPuF

The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion Nature Immunology Russell Jones nature.com/articles/s4159… nature.com/articles/s4159… Preview by Annette Oxenius

AAI Members Dr. Michael Dahabieh and Dr. Russell Jones from the Russell Jones at Van Andel Institute (VAI) found that the immune checkpoint, PTGIR, may be a potential treatment target to re-energize exhausted immune cells to fight #cancer. Learn more: ow.ly/m6Nc50WiHJC.

Happy Canada Day!