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One of my all-time favorite papers which I first read and presented in graduate school. A profound argument for why life chose phosphates rather than sulfates, carbonates or something else, based on elementary physical and organic chemistry principles. archives.evergreen.edu/webpages/curri…

Targeting the “Impossible” Asp12 of KRAS(G12D)(ON) with an Aziridine-Containing Tri-complex | drughunters.com/3WqUOr2 RMC-9805 is a first-in-class, covalent KRAS(G12D)(ON) molecular glue inhibitor from @Revolution Medicines. Read the full article on Drug Hunter

Definitely need these pins!

Halfway there! I really hope we can get to 200! Need to give my undergrads some cool lab pins! #chemtwitter

Inhibitors of histone deacetylases (#HDACs) have longer and longer on-target residence times, which may help future clinical applications. How is this achieved? Check out our new #OpenAccess Perspective JACS Au, with Yasir S. Raouf, to know more! 👇🏻 pubs.acs.org/doi/full/10.10…

Really glad to see this perspective out! Was excellent working together. On to the next! #HDAC #CovalentInhibition

Inhibitors of histone deacetylases have seen a recent rise in strategies focused on extended target residence times via slow-binding and covalent mechanisms. Yasir S. Raouf and Carlos Moreno-Yruela reflect on this emerging paradigm in their perspective 👉 go.acs.org/bZ8

Thank you for sharing! JACS Au

Incredible!