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I am excited to share our new paper published today Cell (link: authors.elsevier.com/a/1jw%7ElL7PXq…). This is one of my favorite studies and took ~7 years to complete. In early 2018, we started the project, aiming at understanding the neural plasticity of the Winner effect. 1/6

Happy to share our latest work showing that an ancient ER-localized RNase IRE1 coordinates with p53 to silence taxane-induced dsRNA and protect immune-cold TNBC from pore-forming pyroptosis. ⁦Cell⁩ ⁦MD Anderson Cancer Center⁩ cell.com/cell/abstract/…

Great talk as always from the incredible @Profa_Correa at the steroid hormones and receptors meeting #SHR2024

Please join us at the Inaugural Symposium of the Center for Genomic Health Shuibing Chen Weill Cornell Medicine Weill Cornell Medicine Surgery Nov 14th 9AM Keynotes: Dr. Francis Collins NIH and Dr. Lorenz Studer Lorenz Center for Stem Cell Biology at Sloan Kettering

Today in Cell we report a new pathway of ketone metabolism. This BHB shunt generates an orphan family of anorexigenic ketone metabolites that are chemical cousins of exercise-inducible Lac-Phe. Congratulations María D. Moya-Garzon Sarafan ChEM-H cell.com/cell/fulltext/…

Another amazing collaboration with Long Lab resulted in the discovery of a new pathway for anti-obesity ketone metabolites. Congratulations to Emma@emmawan01039349 sciencedirect.com/science/articl…

.Stanford University, BCMHouston researchers et al discovered a new metabolic compound that regulates #bodyWeight. Long Lab Dr. Yong Xu Cell Texas Children's genengnews.com/topics/drug-di… via Genetic Engineering & Biotechnology News

doi.org/10.1016/j.meta… I'm so excited to share that my latest publication is officially out!

.Dr. Yong Xu, Kristie (Conde) McDermott, PhD et al reveal brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake. #GABA #serotonin #dopamine #obesity BCMHouston #Metabolism bcm.edu/news/integrati…

What steps does the #brain take to satisfy #hunger? Dr. Yong Xu et al uncovered new circuits and messengers involved in the process. #Metabolism BCMHouston #GABA #dopamine blogs.bcm.edu/2025/01/23/fro…

NIH funding is crucial for many reasons.

Today in nature, we share our latest paper. We developed an algorithm to predict novel peptides cleaved by proconvertases across all human tissues. Using this method, we identified BRP, a brain-derived anti-obesity peptide. nature.com/articles/s4158…

We described a neural mechanism for motion-induced hypothermia which can also be targeted to treat obesity. Congratulations to ⁦Longlong (Lucas) Tu⁩ who started this scientific journey trying to understand his own miserable suffering from motion sickness. nature.com/articles/s4225…

A personal interest in #motionSickness led them to discovering potential new options for treating #obesity. Dr. Yong Xu Longlong (Lucas) Tu explain. Nature Metabolism BCMHouston #BCMPostdoc #brainCircuit bcm.edu/news/motion-si…

Will move the Xu lab to beautiful Tampa and build a new Center for Molecular Psychiatry at USF. The last group photo at the “fountain” serves as a good reflection of my wonderful 14 years at BCM. Many good memories in the past and many great things ahead…

The termination of NIH's MOSAIC program is a massive loss for the next generation of researchers and threatens the future of the research workforce and human health. We remain committed to supporting MOSAIC Scholars with critical professional development resources for the

The Rutgers Center for NeuroMetabolism is officially hiring faculty at all levels. Apply now! jobs.rutgers.edu/postings/248924

RESEARCH | Longlong (Lucas) Tu, Dr. Yong Xu et al. (BCMHouston): Glutamatergic #neurons in the medial vestibular nucleus mediate motion-induced hypothermia and can be targeted to prevent diet-induced #obesity 🧠 nature.com/articles/s4225…

RESEARCH BRIEFING | Longlong (Lucas) Tu, Dr. Yong Xu et al. (BCMHouston): Vestibular nucleus mediation of motion sickness has implications for #obesity control 🧠 nature.com/articles/s4225…

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank Chaolin Zhang Hachung Chung at Columbia University Lena Steckelberg More to come nature.com/articles/s4158…