Our December issue is LIVE! 🚨🎄❄️ It features Reviews on: - Cancer induced pre-conditioning of distant organs, - Strategies to investigate the biology of early cancer, - Precursor multiple myeloma - & a #Roadmap on mRNA splicing in the clinic bit.ly/4i3cnaG

ALSF is pleased to offer grants for early career childhood cancer researchers. We are currently accepting applications for grants in the following categories with deadlines approaching in December: Young Investigator Grant: The purpose of this grant is to find cures and better

Fructose is a ubiquitous dietary ingredient and can fuel tumors. However, cancer cells lack enzymes to break down fructose, but liver cells can convert fructose into circulating LPCs, which enhance tumor growth through a cell non-autonomous mechanism. nature.com/articles/d4158…

Congratulations! It's a proud moment for chess, a proud moment for India, a proud moment for WACA, and for me, a very personal moment of pride. Ding played a very exciting match and showed the champion he is. International Chess Federation WACA_Chess

🇮🇳 Gukesh D 🥹 Ladies and gentlemen, the 18th WORLD CHAMPION! #DingGukesh

Prostaglandins made by tumor cells reprograms immune cells, leading to an interesting clinical hypothesis. nature.com/articles/d4158…

In case you missed it: In this Review, @AlanaWelm & Co discuss the importance of #PDX models for functional precision oncology and how integrating these models with #AI can enhance their utility for personalizing cancer treatment. Huntsman Cancer Institute nature.com/articles/s4156…

New preprint for the new year! We show that lactate drives NTP synthesis via lactylation of the nucleoside diphosphate kinase NME1 in pediatric gliomas. Deuterium metabolic imaging of lactate production interrogates tumor growth and therapy response. biorxiv.org/content/10.110…

Happy to share Emily Baker, Ph.D. preprint on mitochondrial metabolism and kidney cancer metastasis--This ongoing project started with Kimryn Rathmell using patient data to show inhibition of oxphos promotes EMT and primary tumor escape. Great work Emily! biorxiv.org/content/10.110…

If you're finishing a Ph.D. and looking for a postdoctoral position in 2025 in Cancer Biology, apply to our in-person recruiting event at Emory University's Winship Cancer Institute. Deadline is January 31st: apps.winshipcancer.emory.edu/admin/Event/64…

Assistant or Associate Tenure-Track position in the Dept. Cancer Biology open: careers.luc.edu/postings/30627 Advantages: 1) Tenure at Loyola = 'real tenure'. 2) Positions are based on 'hard money' positions. 3) Startup packages are competitive. 4) Faculty environment is OUTSTANDING.

#COMMENT 🚨 Zuber and Palm highlight how modelling tumour-specific metabolic conditions can enhance our understanding of cancer biology & improve therapeutic discovery. 📖 👇 bit.ly/42APSEM

REVIEW | Kivanc Birsoy, @abu_remaileh and colleagues (Rockefeller University, Stanford University) The authors provide a broad overview of the fundamental aspects of #choline #metabolism and cellular handling, and how it impacts #physiology and pathology 🐭👥🧫 nature.com/articles/s4225…

Things I wish more people knew about doing science in the US (thread):

US science is under attack ‘Americans who value the spirit of discovery — and eagerly await new ways to confront disease, strengthen our economy and improve the quality of human life — need to issue a strong outcry.’ – Harold Varmus

#NIH

Strong article from Tom Maniatis, head of the NY Genome Center, on the history of the NIH and its role in maintaining U.S. scientific leadership. Safeguarding the future of biomedical science in the United States: Cell cell.com/cell/fulltext/…

We should be proud, as Americans, of the #NIH and what it has accomplished with our tax dollars.

Funding childhood cancer research and care should be a no-brainer, yet we keep returning, sharing our stories, and pushing Congress to act. #ActionDays2025 A special thank you to my Congressman, Jimmy Panetta for supporting childhood cancer community. #FundingMatters

👇🏻👇🏻A great new way to advance our field together! 💪🏻