Promoting regenerative responses in a pulmonary fibrosis model! Victor J. Thannickal & team Tulane Medicine discover blocking CTLA4 in immune cells induced regeneration and reduce fibrosis in a mouse model of idiopathic pulmonary fibrosis: jci.org/articles/view/…

See the press release here: istesso.co.uk/ground-breakin…

Complex I inhibitors promote tissue regeneration in RA and fibrosis, offering a new therapeutic path for healthy aging and resilience. longevity.technology/news/mitochond… #longevity #HealthyAging #Mitochondria #TissueRepair #ChronicDisease

Phenotypic Pharmacology of Novel Complex I Inhibitors Eliciting Tissue Repair Concurrent to Control of Inflammation. jpet.aspetjournals.org/article/S0022-…

The path to solving disease is oral medicines that repair and regenerate tissue damage, and build resilience to decline. AI not required.

Greater capacity to repair…

Fascinating work in the regulation of haematopoetic stem cell number.

Capacity to repair declines with age. This is exactly the problem Istesso is solving.

David Sinclair Centenarians show us longevity isn’t luck — it’s resilience in action. Delayed disease, slower decline, deeper connection. The lesson isn’t just to add years, but to add coherence across them.

Precisely

Really interesting article. From our perspective, particularly that resilience declines with age and sets a physical limit on lifespan. Augmenting resilience (capacity to adapt, repair and recover) *should* be a breakthrough intervention.

And if we could resolve the repair process that might be an interesting approach to test.

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