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Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control rupress.org/jem/article-ab…

We are hiring! Work in Taiwan with an NIH-scale salary! Please RT!

My lab at Penn is hiring at all levels! We have posted a Research Specialist position on Careers@Penn (link below), and we are also actively looking for postdocs and graduate students. If you're interested in the science of sleep and neurodegeneration, please consider joining us!

Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits || Meningeal

RORγt+ DCs are key to maintaining intestinal immune balance and preventing inappropriate immune responses to food antigens The Colonna Lab Cell Patrick Rodrigues cell.com/cell/fulltext/…

Excited to share that our work by Patrick Rodrigues and Tong Wu is published in Cell: RORγt+ DCs are required to induce oral tolerance. Their absence reduces pTregs and impairs oral tolerance to dietary antigens. Read more: authors.elsevier.com/sd/article/S00…

Our news&views piece, masterfully written by Siling Du on this beautiful story by Hanjie Li and his lab, is here: nature.com/articles/s4142…

Thank you Dr. Li and your team for this wonderful work! 🎉

We are excited to share our newest publication from the Blurton-Jones Lab, "Harnessing human iPSC-moceoglia for CNS-wide delivery of disease modifying proteins." sciencedirect.com/science/articl…

Online now: Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia dlvr.it/TKTFtj

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain: cell.com/immunity/fullt… Immunity

Excited to share the review by ⁦Mitchell (Min Woo) Kim⁩ on how brain washing is linked to Neuroimmunology || Glymphatics and meningeal lymphatics unlock the brain-immune code: Immunity cell.com/immunity/fullt…

Thrilled to share invited review with the brilliant NetaRosezweig! in the Immunity special issue on neuroimmune interactions. We explore shared immune pathways in Alzheimer’s & AMD, and chart new directions for cross-disease therapeutic strategies. cell.com/immunity/fullt…

Excited to dig into this special issue on neuro-immune axis! Happy to share our review on microglia states and function by the fantastic Microglia duo Dr. Constanze Depp and Jordan Doman Thank you Kavitha Scranton Immunity for the opportunity cell.com/immunity/libra…

We propose the term ‘microglial lineage’ to categorize both classical CNS microglia and cells with microglial features in peripheral tissues Trends in Immunology doi.org/10.1016/j.it.2… #MicroglialLineage#Microglia#PNSMicroglia#Neuroimmunology#Macrophage#ImmuneCell (1/4)

In this Insights piece, I discuss the recent study by Sun et al. Gardner Lab, which advances our understanding of tolerogenic RORγt⁺ APCs. I also briefly overview current knowledge and future directions in this rapidly growing field. Grateful to JEM for the opportunity.

Murphy Lab Bay #2: proving that science and chaotic shenanigans can coexist. 🙌 Sunny Kim

In a new Review, scientists discuss how interactions between the nervous and immune systems could impact neurological disorders and allergy-related behaviors like food avoidance. Nick Mroz, PhD Anna Molofsky Ari Molofsky Learn more in Science #Immunology: scim.ag/4dkHAV4

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Check out our manuscript Immunity 👇🏼 cell.com/immunity/abstr…

Our study on glioblastoma-associated immunoregulatory astrocytes is out in nature today by Camilo! We identified GBM-derived IL-11 as a regulator of TRAIL+ astrocytes, which limit anti-tumor T cell responses via apoptosis. nature.com/articles/s4158…