Finally out a new paper from the lab lead by Remi Trimbour "Molecular mechanisms reconstruction from single-cell multi-omics data with HuMMuS" doi.org/10.1093/bioinf… #singlecell #multilayernetworks

Tune in this Tuesday for our @slobentanzer who will present his work on the Biocypher Ecosystem at an Open Box Science seminar !

Happy to share our new Nature Reviews Nephrology review: Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease. Led by Veronica Miguel and Isaac Shaw, Free text here: nature.com/articles/s4158…

Lots of questions lately around #benchmarking #foundation #cell #models. At Turbine we spent some time testing published methods, and found that they performed worse than even the simplest approach: using the mean of training samples. turbine.ai/news/do-cell-f…

Excited to meet colleagues at HCA this year in Milan. I will present a poster showing how we can create patient maps from single-cell data by using factor models and considering a multicellular approach. 😄

Post-doc opening to join our lab EMBL-EBI #EMBLEBIresearch to develop/apply #bioinformatics methods to study cellular organization, int/extra cell networks to extract disease mechanisms from sc and spatial multiomic data, with Yvan Saeys, supp by Chan Zuckerberg Initiative 👇embl.org/jobs/position/…

Check out our work on fibroblast activation patterns in HF models! Huge thanks to my co-lead Laura Wienecke 🙏 from Leuschner Lab!

For those interested in repurposing factor models for patient-level comparisons and inference of multicellular programs have a look at the great overview given by Leo of the foundation work and the applications/packages that we have built! Thanks for this 😊

🔵We are seeking a new director! The Centre for Genomic Regulation (CRG) is an independent research institute located on the shores of the sunny beaches of Barcelona. It is part of the public Centres CERCA research system of Catalonia. We have one clear mission: to understand

👉Consider joining us for a post-doc at EMBL-EBI & AstraZenecaUK as part of the EAZPOD program to study multicellular mechanisms associated with #cancer treatment resistance! #postdoc ebi.ac.uk/research/postd…

This was a really fun review to write together, interesting to reflect on why it’s taken so long for CNVs to level up to similar large scale GWAS applications - lots still to do but slowly getting closer to the SNP GWAS world 😀

Are you a student in France studying computer science, statistics, or bioinformatics? French Embassy UK🇫🇷🇪🇺 has opened a new round of internships hosted at EMBL-EBI. Find out more and apply. ebi.ac.uk/about/jobs/int…

Vous étudiez dans une université française ou une Grande École ? Vous souhaitez en savoir plus sur la bioinformatique ? Vous voulez travailler en Europe et vivre à Cambridge au Royaume-Uni ? Ce stage est fait pour vous...

Kidney fibrosis as a molecular process is poorly understood. In this new study together w/ Pepperkok lab @EMBL, we present a time-resolved #multiomics + computational network modeling approach in combination w/ phenotypic assays to study #kidneyfibrosis tinyurl.com/multiomicsCKD

How good is our understanding of signaling pathways? In this study together w/ Savitski Lab @EMBL, we combine multiple state-of-the-art resources to evaluate signaling pathway inference using phosphoproteomics and kinase-substrate networks tinyurl.com/2n43jsc4

We're hiring! Join Saez-Rodriguez Group as a Staff Bioinformatician at Heidelberg University- Work on multi-omics data in heart disease research (CRC 1550). PhD in computational biology or relevant experience required. 📅 Apply by Nov 18, 2024. tinyurl.com/bddyht5s

📢 Introducing CORNETO: a unified, knowledge-driven framework for multi-sample network learning & modeling via constrained optimization, supporting a wide variety of network methods and prior knowledge 💻Code: github.com/saezlab/corneto 📜Paper: doi.org/10.1101/2024.1… 🧵👇

Our work with Lucas Schirmer in multiple sclerosis (MS) is out today in Nature Neuroscience. We investigated lesion progression and cell-cell communication events in MS using snRNA-seq and spatial transcriptomics 🧠 See below ⬇️ nature.com/articles/s4159…

What are the key disrupted multicellular processes in heart failure? In our new work we combine 23 years of molecular data with recent single-cell atlases to draw a cross-study patient map. How did we navigate the heart failure space? 🧵⬇️ doi.org/10.1101/2024.1…

Got a PhD in bioinformatics or quantiative/CS degree? Want to work with AI on real world health care data, using some of the biggest datasets in the world? Want to live in Cambridge UK and work in European EMBL? This job in my research group is for you! embl.org/jobs/position/…