Heitman lab at Duke (@dukeheitman) 's Twitter Profile
Heitman lab at Duke

@dukeheitman

We're the Heitman lab at @DukeMGM. We're interested in sexual reproduction and the emergence and evolution of microbial pathogens. Account run by lab members.

ID: 1099091262739763202

linkhttps://mgm.duke.edu/faculty-and-research/primary-faculty/joseph-heitman-md-phd-2/ calendar_today22-02-2019 23:39:11

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Vikas Yadav (@vikasyadavsci) 's Twitter Profile Photo

Our review about evolution of sex - "the queen of all problems in evolutionary biology" through a microbial perspective was just published in PNASNews. Heitman lab at Duke #fungi #evolution pnas.org/doi/10.1073/pn… Hope you enjoy reading it!

Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

A microbial perspective on the evolution of sex focussing on variations of sexual reproduction in #fungi is out now in PNASNews. This is the inaugural article by Joe, as a National Academy of Sciences member. pnas.org/doi/10.1073/pn…

A microbial perspective on the evolution of sex focussing on variations of sexual reproduction in #fungi is out now in <a href="/PNASNews/">PNASNews</a>. This is the inaugural article by Joe, as a National Academy of Sciences member. pnas.org/doi/10.1073/pn…
Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

Congratulations to Allan Jacobson and Lynne Maquat who received the 2023 Gruber Genetics Prize for landmark studies on nonsense mediated mRNA decay. Allan founded PTC Therapeutics which developed drugs used globally to treat human genetic diseases.

Congratulations to Allan Jacobson and Lynne Maquat who received the 2023 Gruber Genetics Prize for landmark studies on nonsense mediated mRNA decay.  Allan founded PTC Therapeutics which developed drugs used globally to treat human genetic diseases.
Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

An updated version is now available for the study from @magwenelab, which uses the interaction between amoeba and human fungal pathogen Cryptococcus neoformans to test the “accidental pathogen” hypothesis. biorxiv.org/content/10.110…

Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

Excited to share our new preprint on transitions in mating-type locus chromosomal organization in Malassezia and early steps in sexual reproduction biorxiv.org/content/10.110…. Kudos to @MarcoACoelho1, Giuseppe Ianiri and @MrciaDavidPalm1, and all authors, for their contributions.

Excited to share our new preprint on transitions in mating-type locus chromosomal organization in Malassezia and early steps in sexual reproduction biorxiv.org/content/10.110…. Kudos to @MarcoACoelho1, <a href="/giuseppe_ianiri/">Giuseppe Ianiri</a> and @MrciaDavidPalm1, and all authors, for their contributions.
Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

Congratulations to two leading luminaries in fungal genetics, Amy Gladfelter and Regine Kahmann, on their recent election to the American Academy of Arts and Sciences!!! mgm.duke.edu/personnel/amy-… amacad.org/news/2023-memb…

Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

Using surveillance data collected by the French National Reference Center for Invasive Mycoses and Antifungals, a recent report in mBio by the French Mycoses Study Group provides an updated comprehensive overview on the epidemiology of invasive fungal diseases (IFDs) in France.

Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

While the overall incidence of major IFDs and their mortality rate remained relatively stable, the study observed increased fungemia in older population (mainly due to infections by C. albicans), as well as concurrent IFD infections.

Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

The study highlights the importance of active surveillance of IFDs and the collaboration between mycologists and clinicians, calls for research on innovative approaches, include diagnostic tools and new antifungals, that can improve the global survival rates associated with IFDs.

Vikas Yadav (@vikasyadavsci) 's Twitter Profile Photo

We wrote a review on the importance of stress-responsive calcium-calcineurin signaling in fungal pathogens and how understanding this signaling cascade can be extremely fruitful. Read on - Calcineurin: The Achilles’ heel of fungal pathogens journals.plos.org/plospathogens/…

We wrote a review on the importance of stress-responsive calcium-calcineurin signaling in fungal pathogens and how understanding this signaling cascade can be extremely fruitful. Read on - 
Calcineurin: The Achilles’ heel of fungal pathogens

journals.plos.org/plospathogens/…
Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

The latest PLOS Pathogens Pearls article by Vikas Yadav is now out. He reviews the essential roles of calcineurin in the virulence of #fungal pathogens of animals and plants and discusses what future studies should focus on to target this Achilles heel. journals.plos.org/plospathogens/…

The latest <a href="/PLOSPathogens/">PLOS Pathogens</a> Pearls article by <a href="/VikasYadavSci/">Vikas Yadav</a> is now out. He reviews the essential roles of calcineurin in the virulence of #fungal pathogens of animals and plants and discusses what future studies should focus on to target this Achilles heel.
journals.plos.org/plospathogens/…
Vikas Yadav (@vikasyadavsci) 's Twitter Profile Photo

🚨New Preprint🚨 Can signaling cascades modulate expression status even before turning genes on and off in the nucleus? We studied and found a direct role of calcium-responsive calcineurin signaling in RNAi at P-bodies, governing gene expression levels. biorxiv.org/content/10.110…

🚨New Preprint🚨

Can signaling cascades modulate expression status even before turning genes on and off in the nucleus?
We studied and found a direct role of calcium-responsive calcineurin signaling in RNAi at P-bodies, governing gene expression levels.
biorxiv.org/content/10.110…
Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

In the latest PNASNews , we discovered that RNAi-loss is more common than expected in the global population of Cryptococcus neoformans, driving distinct evolutionary paths: hypermutation via transposon accumulation or survival without hypermutation. pnas.org/doi/10.1073/pn…

Heitman lab at Duke (@dukeheitman) 's Twitter Profile Photo

Excited to share our new preprint on confirming the essentiality of four genes in mating-type locus in Cryptococcus neoformans! MYO2, although predicted to be essential, is dispensable for cell viability and important for cytokinesis and pathogenicity. biorxiv.org/content/10.110…