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Who won?

Celebrating Halloween at the lab 🧟🧚🏻‍♂️🧙

College life in a research lab: two students Duke Neurobiology weigh in on how they got here, what they're learning and where they hope to go bit.ly/3fqfZZ4 West Laboratory

Aligning Science Across Parkinson’s ASAPTeamLiddle retreat wrapped up today…what great science was discussed 🤓😍!!!

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase biorxiv.org/cgi/content/sh… #bioRxiv

Interesting new commentary from West and Schwarzschild on LRRK2 inhibitors for PD and their journey through the pharma "Valley of Death." #LRRK2 #Parkinsons West Laboratory …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Congrats to the West Lab 2023 Graduates!! Moving on is bittersweet for us, but what a great job in the lab, you will be missed 🥲

Shoutout to our grad student Samuel Strader publishing an excellent review! The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease portlandpress.com/biochemsoctran…

Congratulations to Zhiyong!!, Our famous K99/R00 awardee and incoming tenure track Assistant Professor in Cell Biology, #UABSOM #GoBLAZERS

Congrats to Nicole!!, our post-doc headed to Vividion Therapeutics shake up the Early Discovery program!

Our undergrad researcher Grace, headed for University of Washington - MSTP , go get em!

Recent Duke Neuroscience honors Graduate, Deney Li, researcher extraordinar, will be heading our michaeljfox.org biomarker research project as a post-bacc! So happy she can stay on!

Congrats to Jon Lin!!, Honors undergraduate researcher who will be starting his program in data science in a few weeks NC State University

Congrats to Amber!!, Our amazing undergrad researcher off to begin her career in medicine

Nanoplastics Create an Environment for Parkinson’s To Develop, Study Suggests | Technology Networks technologynetworks.com/applied-scienc…

New research from West Laboratory & collaborators reports that anionic nanoplastic contaminants potently precipitate the formation & propagation of #Parkinsons-associated α-synuclein protein fibrils, through a high-affinity interaction NAC domains in α-syn science.org/doi/10.1126/sc…

#Cover: Gut mucosal cells transfer α-synuclein to the vagus nerve: buff.ly/3RyFyaH The image shows α-synuclein (red) emerging from an enteroendocrine cell (green) onto a vagal neuron (turquoise). Duke Health #Gastroenterology #Neuroscience

New paper from West Laboratory et al present an ultra-sensitive version of a SiMOA (single-molecule array assay) for measures of LRRK2 kinase activity in serum linking #Parkinsons severity to peripheral inflam.; Accurate measures of pT73-Rab10 to total Rab10 …arneurodegeneration.biomedcentral.com/articles/10.11…

Interesting: West Laboratory LashuelNeuroLab & collaborators report the first atomic structure of mouse α-synuclein fibrils, but find altered packing arrangements,⬇️hydrophobicity, &⬆️fragmentation sensitivity & weak immunological responses (vs human a-syn) science.org/doi/10.1126/sc…

Work led by Arpine Sokratian in Andy West's lab unveils the structural underpinnings of alpha-synuclein pathogenicity: Mouse alpha-synuclein fibrils display unique features compared to humans, impacting disease models. More here: doi.org/10.1126/sciadv…