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Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome, according to a paper in Nature Microbiology. go.nature.com/4i3gqUI

A new genomic study in Science encompassing more than 300 genomes spanning the last 50,000 years has revealed how a single wave of Neanderthal gene flow into early modern humans left an indelible mark on human evolution. scim.ag/3OWzma0

Efficacy and Safety of Telitacicept as an Add-On Therapy for Refractory Immunoglobulin A Nephropathy or Immunoglobulin A Vasculitis Nephropathy in Children ⁦KIReports⁩ #OpenAccess #IgA_Nephropathy kireports.org/article/S2468-…

[LAURÉATS 2024] 🏅Félicitations à Ilies Benotmane, lauréat du prix Drieu-Cholet pour ses travaux sur la #transplantation #rénale #Covid" CHRU Strasbourg SFT JUNIORS Inserm 🛜 bit.ly/3ZYIAZG

CM-TMA has a classical pathway stimulus driven by polyreactive IgM, addressing why 40% of CM-TMA lack complement-specific variants. ow.ly/ISuO50Uq9rH #thrombosisandhemostasis #immunobiologyandimmunotherapy

Management strategies for IgAN based on clinical presentations: ▫️Classic IgAN +/- proteinuria ▫️IgAN w/macrohematuria ▫️Pure nephrotic syndrome ▫️Rapidly progressive/Crescentic IgAN ▫️IgAN w/malignant HTN/TMA ▫️IgAN w/pregnancy ▫️Post transplant IgAN 🔗 doi.org/10.1093/ndt/gf…

Le père Noël a un message pour vous !

The membrane attack complex drives thrombotic microangiopathy in complement mediated #atypicalhemolyticuremicsyndrome. doi.org/10.1016/j.kint… #OpenAccess #MedTwitter #NephTwitter #aHUS #complement Newcastle University Cardiff University

🎉 #RACJN 🎉 Oyé oyé, regardez ce magnifique programme ! 🦾 Aix en provence, "urgences en néphrologie", inscrivez vous vite 💨

An absolutely fantastic meeting!!! Thanks for capturing moments from our exciting conversation Dana Rizk, Isabelle Ayoub, #VeroniqueFremeauxBacchi🤩 Int Society of Nephrology

Brief Report: Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease nej.md/42XF03F Editorial: Progress in the Development of N-of-1 Therapy nej.md/3EUA1rr Science behind the Study: Personalized Gene Editing to Treat an Inborn Error of

C3G and Ig-MPGN—treatment standard doi.org/10.1093/ndt/gf… ➡️The authors review the current standards of treatment and discuss novel developments in the pathophysiology, diagnosis, outcome prediction and management of C3G and Ig-MPGN

Neutrophils, once seen as uniform, are diverse with key roles in immunity. Their release of NETs—DNA and proteins—shapes kidney health. RT! PMID:40102634, Nat Rev Nephrol 2025, Nature Reviews Nephrology doi.org/10.1038/s41581… #AI #Pharma #BioMed #RNA #ASHG #ESHG

Fibrillary glomerulonephritis: an observational study of clinical-pathological features and outcomes in patients from a multi-institutional cohort academic.oup.com/ckj/article/do…

Delighted to share our latest study on the complement anaphylatoxin receptors 😎!!! Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors biorxiv.org/content/10.110…

1/n We profile a broad set of C3aR/C5aR1 agonists on the human/mouse receptors, and uncover some very interesting pharmacology and functional specialization. For example, C5a-d-Arg, the naturally-encoded version of C5a, acts as a robust G-protein-biased agonist at C5aR1!

Diagnostic Value of #Biological Parameters in #BiopsyConfirmed Thrombotic Microangiopathy #TMA MATRIX Consortium Group #VisualAbstract by Susan Thanabalasingam kireports.org/article/S2468-…

Altered heparan sulphate architecture causes FHR-1 to disrupt FH function, increasing complement activation on mesangial cells. This is similar to how GAG changes in the blood/retinal barrier affect complement activity. #GAGs #FHRs #complement buff.ly/No5uT9h

MPO-ANCA associated vasculitis with prominent necrotizing arteritis. Interestingly, the arteritis in this case was very active despite only rare ~10% fibrocellular to fibrous crescents in glomeruli. #renalpath #pathtwitter #nephrology

📰 New in AJPC: State-of-the-Art Review on Preeclampsia—exploring pathophysiological mechanisms and preventive strategies for better maternal heart health. Read it here 👉 ow.ly/tQCB50Wkqac #PreventiveCardiology #Preeclampsia #WomenHeartHealth #AJPC #CardiologyResearch