Missed #MPS2025? Here's a quick venue tour! 🎥 Visit us at booth #202 for: PDMS-free biochips 🧪 High sample recovery 🔬 Infection models 🦠 No-capital tech 💡 Advanced cancer models 🎯

“I am always excited to have something new in the lab” Anne talks about how she uses our liver-on-chip model for #toxicity screening. Meet Anni today at #MPS2025 at her poster "Microphysiological #organonchip models for therapeutic antibody validation and safety testing"

🎉 Congratulations to Nanci Santos Ferreira for submitting the closest guess in our competition and winning a LEGO® clean bench. We are sure it will make a nice addition to your collection.

In part 1 of our #MPS2025 interview series, we spoke with Valentin Wegner, a PhD student at University Hospital Jena, about his research on enhancing CAR T-cell efficacy using short-chain fatty acids in an intestinal adenocarcinoma-on-chip model --> zurl.co/fF49y

In part 2 of #MPS2025, we interviewed Dr. Manasa Nandimandalam from Hannover Medical School about her advanced in vitro models simulating intestinal environments for infection and inflammation studies. -->zurl.co/g6QPH

In part 3 of our #MPS2025 series, we interview Kristin Schüler, a PhD student working in Portugal, about her novel scaffold for collagen deposition in cartilage engineering and osteoarthritis modeling. --> zurl.co/WqFLJ #organonchip

In part 4 of our #MPS2025 series, Dr. Santamarina (ITQB NOVA, Portugal) discusses the Horizon EU Twinning Project MPS NOVA Twinning with Cláudia Santos (NOVA Medical School), focusing on chronic diseases & host-microbe interactions using organ-on-chip tech --> youtu.be/zdyFzlrDlf4

Part 5 of our #MPS2025 series highlights Inês Silva, a PhD student at NIMSB_NOVA, Portugal. She developed a microphysiological method to study dopaminergic injury and inflammation in Parkinson’s disease. --> youtu.be/5eqEredyMOg MPS NOVA Twinning

Part 6 of our #MPS2025 series: Meet Daniela Marques, PhD student at NIMSB_NOVA, Portugal. She develops a microglia crosstalk MPS model of the blood-brain barrier to explore polyphenol metabolites' potential --> youtu.be/Pp50aTpxDVo MPS NOVA Twinning

Part 7 of our #MPS2025 interview series highlights Adrian Feile, a PhD student at University Hospital Jena. He explores how DPO-dependent quorum sensing affects Vibrio cholerae biofilm behavior in a 3D intestine-on-chip model --> zurl.co/9wE8k

🚀 Exciting news! Dynamic42 GmbH is joining the German Accelerator U.S. Market Access Life Sciences program alongside Green Elephant Biotech, CUREosity GmbH, INTU Diagnostics & Sensific GmbH. A pivotal time as FDA & NIH advance non-animal methods like #organonchip tech.

MPS vs. OoC OoC = specific type of MPS OoC uses microfluidic chips, MPS doesn’t need to MPS = mini in vitro models of organs/tissues OoC replicates organ environments with dynamic functions Key difference: MPS doesn’t always need biomechanical stimulation.

#Organonchip models represent the minimal viable unit of an organ using biochips with parallel channels separated by a membrane. They support tissue growth, nutrient transport & simulate forces like blood flow for realistic drug & immune response studies.

Understanding how the body is composed, how different molecules and pathways can change and affect each other is what drives Tim to explore microphysiological systems such as #organonchip to recapitulate human physiology and dissect individual organ models.

Key Feature I: Blood Flow 🌊 Organ models on biochips with microfluidic pumps mimic real human blood flow (pulsatile & laminar), supporting in vivo-like cell growth. Watch the medium flow from reservoir ➡️ channels ➡️ biochip chambers with epithelial & endothelial cells!

Having to work with mice at university, Anne, our head of team liver, realized quite quickly that this wasn’t the right way for her. Looking for alternatives, that still could deliver comprehensive results, she found #organonchip technology and hasn’t looked back since.

Key features part II – Immunocompetence: The immune system defends against infections, removes diseased cells, and maintains tissue balance. Organ models mimic this complexity with integrated immune cells. #Immunology

Key features part III – Microorganism Complex organ models allow for the integration of a microbiome or pathogens to enable the establishment of complex disease and infection models.

Looking forward to joining the meeting!

Key features part IV – Molecular Gradients: in #organonchip controlled microfluidic perfusion shapes biological responses, modulating molecular patterns in vascular tissues via tissue interfaces & biochip geometry.