2nd labnewsflash of the week...it’s a great pleasure to introduce founding postdoc of my lab MRC-Uni of Glasgow Centre for Virus Research...🥁 Arda 🍾 Arda is swapping S. typhi for S. CoV and has the unenviable first task of helping me track down the missing Gilson order. Very excited for your start! 🥳

I will soon be recruiting a postdoc to join my lab (bioengineering.dtu.dk/usi). We work on things related to ubiquitin, inflammation, and metabolism. Get in touch if you have a project in mind and are interested in joining (DM or email). Please pass it on. Official ad will follow.

ONE WEEK LEFT 🚨 *New vacancy* Research Technician (deadline 22/04) to carry out research on #viral manipulation of host cell signalling pathways with Adam Fletcher! 🦠 For info 👉bit.ly/CVR-Vacancies Apply 👉 gla.ac.uk/explore/jobs/ Ref 054147

Join us in exploring virus-regulating E3 ligases, cellular and viral. The post is funded until Feb 2025. Application deadline extended to 6 May.

Great story beautifully told

Inner workings of the giant E3 RNF213 revealed. It uses a cysteine nucleophile and is regulated by ATP! Fantastic collaboration with @clausen_lab Juraj Ahel Adam Fletcher biorxiv.org/content/10.110… #ubiquitin #E3

Fantastic collaboration ⁦Satpal Virdee⁩ Juraj Ahel⁩ ⁦@clausen_lab⁩ wherein we show how the largest single-chain E3 in mammals couples ATP binding to an unusual Ub transfer. Extremely exciting implications for metabolic sensing. #RNF213 biorxiv.org/content/10.110…

There’s an uncanny resemblance to a UK map in the RNF213 structure. Is that the E2 docked in Dundee?

Hats off to the newly minted Dr Balci Arda on passing his viva with flying colours! His PhD journey was far from ordinary but Arda’s emerged an exceptionally thoughtful and talented scientist. Watch this space!

🚨 *New #Vacancy* #ResearchTechnician (deadline 15th July) to maintain #tick colonies and carry out research on #tickborne #viruses with Brennan Lab CVR 🦠🕷🦟🔬🧫 🕷️🦠 For info 👉 gla.ac.uk/researchinstit… Apply 👉 gla.ac.uk/explore/jobs/ Ref 061974

🚨 *New #Vacancy* Research Assistant/Associate (deadline 9th Aug) to use cryo-ET, -CLEM & -FIB to understand the replication machinery of clinically important negative-sense RNA viruses. For info 👉bit.ly/CVR-WorkWithUs Apply 👉 gla.ac.uk/explore/jobs/ Ref 061867

It was great writing this Perspective with my man Dan Squair on the new world of non-lysine ubiquitination. Exciting times! nature.com/articles/s4158… nature.com/articles/s4158…

Thanks Suzannah for launching this.

📢 Calling anyone working on/with blood-borne viruses (e.g. HIV, Hep C) in SCOTLAND! Are you passionate about shaping the future of research funding and support for folks living with these viruses? Intrigued? Drop into the comments here 👇

Another plug for a vacancy in my lab where we explore all things virus-induces-e3-restricts-replication (or try to) at the intersection of virology and biochemistry and a sprinkling of chemistry for good measure. We like to think BIG! Do get in touch with any informal enquires👇

Don't think about it... great research, great lab and great supervisor!!! 👍👌

A sad week in the Fletcher lab as we say buen viaje to Roosa Harmo our stalwart technician! Roosa joined me a year ago as the lab was emerging from cardboard boxes and has worked tirelessly to provide us with more reagents than you can shake a pipette at. We’re going to miss you!

Congratulations Narut. It’s been a pleasure having you in the lab and you’ve achieved more than I anticipated someone could in 10 weeks. Best of luck with your future studies!