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ANGIOMATOID FIBROUS HISTIOCYTOMA >Thick fibrous pseudocapsule >Prominent lymphoid cuff mimicking a lymph-node metástasis >Hemorrhagic cysts spaces without endothelial lining. Spindled or histiocytoid cells arranged in a nodular pattern >EWSR1-CREB1 fusion gene #BSTPath #Pathology

Cyto for you Pepe Jiménez Heffernan 👍🙏🤗

Hyalinizing clear cell carcinoma, salivary glands. Most in minor salivary glands. Unencapsulated. 🔬 Cords/trabeculae/nests of bland clear and/or eosinophilic cells in a hyalinized stroma. Most have EWSR1:ATF1 fusion. #pathology

FLAME CELLS should never be considered specific for Graves’ Disease on thyroid FNA smears stained with Giemsa. This case was called “Follicular Neoplasm” on FNA with a follow-up diagnosis of “Follicular Carcinoma” on resection.

Work smarter, not harder.

Claudin 18.2 immunohistochemistry is new for gastric and esophageal adenocarcinomas. Benign gastric mucosa is the internal positive control. 2+-3+ membrane staining in ≥75% of tumor cells is the cutoff for use of anti-CLDN18.2 (zolbetuximab). #UMiamiPath PMID: 39098518.

he is warm and comfy

60s M posterior peripheral RLL lung mass. Pleural fluid cytology. Dx? #PathX #PathTwitter #ThoracicPath

At least 24,090 of those injured in #Gaza are estimated to have life-changing injuries that require rehabilitation services now and for years to come. But with the health system decimated, rehabilitation and specialized care are not available. WHO reiterates its call for a

Friday Fun! Things are not always what they seem. What is your diagnosis? #breastpath #PathTwitter #PathX WashU Medicine Pathology & Immunology WashU Medicine Pathology & Immunology Education

COMPOSITE HEMANGIOENDOTHELIOMA WITH NEUROENDOCRINE MARKER EXPRESSION (Neuroendocrine CHE) An aggressive variant that can arise superficial or deep, and usually shows areas of retiform HE, epithelioid HE, and tumor nests. No known recurrent fusions. + for CD31, ERG, NE markers

Thank you all for taking part in the case I posted last Friday. I chose one of the trickier fields to share with you, because of its educational value. The additional images provide more insight into the diagnosis. Let's go over the answers 1 by 1🧵 #breastpath #PathTwitter

Endocervical Adenocarcinoma In-situ (AIS) is much easier to appreciate in a PAP test on fragments seen on their SIDE ("Flat Strips"), compared to when they are seen "EN FACE". (SurePath)

Like an "eye of a storm" - Papillary Thyroid Carcinoma with cellular swirling ("onion skinning"). (Thyroid FNA)

Time for the last case (case 5) of last week's series of p63 pitfalls. I might include one more in the coming days just for fun. In this case, we have a proliferation of malignant cells in anastomosing ducts with a desmoplastic response, invasive by H&E in my opinion, but with a

Axillary lymph node 😃benign or malignant? Dr. Luca Olaleke Folaranmi Fouad Boulos Raza Hoda MD Alexander Damron, MD Brian McMillen MD Liza Quintana, MD Tania Labiano Aurélien Morini, MD, MSc 🇫🇷🇪🇺💙💛 Celina Stayerman MD Nusrat Z. Bokhari Amal Asar, FRCPath, MAcadMED Tristan Rutland MBBS FRCPA IFCAP Israh Akhtar Khan Lorand Kis Padma Priya J Barry McGinn Pascual Meseguer Med Amine, MD 🔬

60s M 20cm thigh mass. S100=very few scattered cells; SOX10= scattered cytoplasmic staining; PRAME=80% of cells +; CK, desmin, SMA, h-caldesmon, CD45/43, ALK, MYOD1, CD34 etc negative. Dx/workup? #BSTpath #PathTwitter #PathX

Congratulations to the brilliant Eyas Alzayadneh إياس زيادنة for a stellar #gynpath #UVAPath fellowship year! As I said in my graduation remarks, I spend more time with this fellow than I do with anyone outside my own immediate family, & all that time with him has been a true delight.

Scalp mass. Mucinous Eccrine carcinoma. If skin primary, prognosis is good. If metastatic, the primary could be mammary colloid carcinoma (ER+, PR+, CK20+) or mucinous GI carcinomas (CDX2+, CK20+). #dermpath #dermatology