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New U.S. FDA accelerated approval: Sunvozertinib for EGFR exon20ins NSCLC after platinum chemo ▫️n=85, WU-KONG1B ▫️ORR: 46% ▫️DoR: 11.1 mo ⚠️ Diarrhea, rash, ⬆️ CK OncoAlert Exon 20 Group, a multistakeholder organization #lcsm

⭐️FDA grants accelerated approval for sunvozeritinib, EGFR exon 20 TKI, based trial WU-KONG1B (NCT03974022) ➡️184 patients were in primary analysis. ➡️23.7% had baseline brain mets; thought these had to be treated (ie not ACTIVE brain mets) ➡️All patients received prior

Heterogeneity and co-occurrence of resistance mechanisms in EGFR-TKI-induced NSCLC to SCLC transformation: a case report acr.amegroups.org/article/view/1…

📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression. 🧠🧬🔬 Read: doi.org/10.1016/j.ccel…

AXL enhances the self-renewal of cancer stem-like cells and Osimertinib chemoresistance by regulating SCD1 in non-small cell lung cancer sciencedirect.com/science/articl…

Online Now: Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps dlvr.it/TLjsMp

Thanks to ecancer ecancer en español for the interview about ASCO 2025 Summary in NSCLC with Highlights From CheckMate 816, Delphi-304, Tarlatamab & NeoADAURA Trials ecancer.org/en/video/12442… SmallCellSMASHERS EGFR Resisters EGFR Resisters Research Summit EGFR Positive Lung Cancer UK Roche EGFR EGFRm NSCLC Dana Farber's EGFR-Mutant Lung Cancer Center

People with #lungcancer & low BMI are more likely to develop brain metastases - a link not seen in other cancers. New open access study in Nature Communications, July 2025. Researchers suggest it’s driven by brain signalling changes, not just weight loss. 🔗

In Aug ’21, I was unwell, had 2 biopsies & waited weeks for answers. A liquid biopsy trial gave me an ALK+ #lungcancer diagnosis in 10 days. Now NHS England is rolling this out! 🎙️ Alastair Greystoke & I spoke w Roy Castle Lung Cancer Foundation on this & more: 👉 roycastle.org/our-support/po… #LCSM

Have you caught up on Episode 1 of LungCancerRx 🫁💊 yet? Your refill is almost due… because Episode 2 drops NEXT WEEK! 🎧💥 Oncology News Central Eric K. Singhi, MD Fawzi Abu Rous, MD Aakash Desai, MD, MPH, FASCO Jill Feldman

Excellent survival benefit achieved in patients with advanced-stage non-small cell lung cancer harboring the epidermal growth factor receptor-G719X mutation treated by afatinib: the real-world data from a multicenter study in Vietnam journals.sagepub.com/doi/10.1177/17…

Case Report: Peritoneal and small bowel metastasis from lung adenocarcinoma with EGFR L858R mutation frontiersin.org/journals/oncol…

“This study demonstrates the utility of longitudinal pharmacogenomic analysis to develop treatment strategies according to individual tumor evolution type.” nature.com/articles/s1227…

Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non–Small Cell Lung Cancer Patients aacrjournals.org/cancerrescommu…

We don’t talk enough about what it’s like to lose the friends you met through cancer. It’s a grief layered with love, trauma, and deep understanding. Leah & Cori, two patients with lung cancer, open up 🎥👇 #CancerGrief #LungCancerAwareness

🎯 EQUAL SPOTLIGHT After losing multiple family members to lung cancer and being diagnosed at 39, Jill Feldman searched for answers and a community. She helped build EGFR Resisters and now fights for equity in lung cancer screening. #EQUALStudy #LungCancer #HealthEquity

#FlorezLab Jill Feldman EGFR Resisters Narjust Florez, MD, FASCO Dana Farber's EGFR-Mutant Lung Cancer Center ASCO Lung Cancer Research Foundation Coral Olazagasti, MD Maria Antonia Vélez Idalid "Ivy" Franco MD MPH Ivy Riano, M.D. Great grandfather, grandfather, father, 2 uncles and an aunt (all died from lung cancer) and a chronic cough and I still didn’t qualify. Took a car crash. I’m still told it isn’t hereditary. I want my children to have access to testing!

Such a treat to discuss this important approval and learn about the history of Sunvozertinib development and trial design and nuances of dose/toxicities from Dr James Yang. Thanks Stephen V Liu, MD IASLC #lcsm EGFR Resisters

I am honored to receive an National Comprehensive Cancer Network (NCCN) grant to support research aimed at advancing care for patients with EGFR-mutated lung cancer EGFR Resisters prn.to/4eGAJWG

🔍 We’re looking for the next wave of leaders in EGFR-mutated NSCLC! Submit your abstract or career statement and join us Nov 6–8 in Chicago. 🗓 Deadline: Aug 8 Register here: ceconcepts.com/egfr-summit Zosia Piotrowska Jill Feldman #LungCancer #LungCancerResearch #EGFR #EGFRSummit