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I’m happy to share our newest preprint, ‘Pseudomonas fluorescens 15 small RNA Pfs1 mediates transgenerational epigenetic inheritance of pathogen avoidance in C. elegans through the Ephrin receptor VAB-1’ biorxiv.org/content/10.110…

RESEARCH | Chen Lesnik חן לסניק 💔, Rachel Kaletsky, ctmurphy1.bsky.social et al. (Princeton University): In C. elegans, branched-chain amino acid catabolism is important for maintaining oocyte quality with age 🪱 nature.com/articles/s4225…

biorxiv.org/content/10.110…

Now in Current Biology , we show that gap junction-mediated bioelectric signaling is required for the development and function of slow muscle. cell.com/current-biolog…

So honored to be selected as an LSRF Life Sciences Research Foundation fellow supported by Simons Foundation Autism Research Initiative . Thank you to the amazing ctmurphy1.bsky.social for her insight and guidance as I've started new projects in the lab, and to all my mentors (especially Diana Libuda) who have believed in me! lsrf.org/current-fellow…

The last of my graduate work with Diana Libuda is out in eLife - the journal! We show that BRCA1 and SMC-5/6 regulate DNA break repair pathway engagement in C. elegans meiosis, but are not required for intersister repair. A fun "crossover" collab with The Rog Lab! elifesciences.org/articles/80687

We created a comic book based on our research on the role of GJ channels and bioelectricity in neuromuscular development! This was an amazing collaboration with undergraduate art student Bentley Smallwood.🐟🔬⚡️ Read the whole version here: opentext.uoregon.edu/science-comics… #Zebrafish

Our new paper is out nature We report that fibrin drives toxic inflammation, impaired viral clearance & neuropathology in #SARSCoV2 infection treated by #fibrin antibody #LongCovid #Coagulation #Immunotherapy #fibrinogen #COVID19 nature.com/articles/s4158…

When I started my postdoc, I asked if partial reprogramming could rejuvenate aging worm neurons. It turns out, these worm OSK factors are neutral or even deleterious to C. elegans lifespan and chemosensation! Thanks to ctmurphy1.bsky.social and Rachel Kaletsky for their help and support!

@dkjhaunc Charles Brenner, PhD I agree with Charles Brenner, PhD - we are only showing that it didn't work in worms, so the question is, Why? But I also agree that negative results like this should be viewed simply as "results" that tell us more about biology

Funniest thing sent to me today: thefamousjackets.co.uk/the-today-show…

We are thrilled to present you our work on BRCA1-BARD1 nature showing that the complex has a direct role in long-range DNA end resection. With Ilaria_Ceppi Maria Rosaria Dello Stritto and our collaborators Pablo Huertas' Lab Sylvie Noordermeer and Seidel labs. nature.com/articles/s4158…

BioRxiv: Synaptonemal complex protects double-Holliday junctions during meiosis dlvr.it/TDGpHH

Can we use CRISPR screens to identify genes that drive neural stem cell aging? Super excited to see this work published nature! Huge congrats to Tyson @ruetz_tyson, Angie Pogson, Chloe Kashiwagi, and all authors! Great collaboration with Michael C Bassik! nature.com/articles/s4158…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals,

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in Current Biology, led by Ninadini Sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)

At the end of 2018 I was lucky to receive a CZI Science Ben Barres award. This preprint is the culmination of that funding, which allowed us to try "out of the box" ideas to study neurodegeneration. Fearlessly led by amazing student Mitali Tyagi! 🧵 /1 biorxiv.org/content/10.110…

Structural duality enables a single protein to act as a toxin–antidote pair for meiotic drive | PNAS pnas.org/doi/abs/10.107… & A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring | PNAS pnas.org/doi/abs/10.107… 2 amazing papers! 🤩