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Wonderful that beans will finally have its well deserved place in the guidelines 🌱 Christopher Gardner

4. Improving cognition in old mice Cognition slows down in old age - partially due to reduced transcription of mitochondrial DNA, which reduces ATP production in neurons This study engineered the CREB transcription factor to be continuously active, specifically in mitochondria

Cardinal sin in #amyloidosis workup➡️Ordering a PYP scan as the next step in a patient with HFpEF and Lambda LC monoclonal gammopathy!

#VTE

Consuming any type of alcohol – beer, wine, or spirits – increases the risk for at least seven types of cancer, including cancers of the breast for women, colorectum, esophagus, liver, mouth, throat, and voice box (larynx).

Congress should authorize an update to the Surgeon General’s warning label on alcohol-containing beverages to include a cancer risk warning. The advisory also calls for a reassessment & revision of the guideline limits for alcohol consumption to account for increased cancer risk.

I hope #MMSM will indulge this thread on autologous SCT for myeloma: In this letter (rdcu.be/d5pZ0), I highlight that a recent RCT of ASCT, EMN02, only demonstrated overall survival benefit to ASCT on long-term follow-up, after publication of the primary analysis. 1/9

Don’t hesitate to seek support. It makes a difference! This is an excerpt from the just-concluded Conversations on Cancer panel discussion 📺 ICYMI, watch the replay here: youtube.com/live/DpL5se094… #OCEProjectCommunity #ConversationsonCaner #Cancercare

More than half of patients newly diagnosed with lymphoma or myeloma experience significant anxiety or depression - we should expect therefore that the majority of these patients will need treatment. #mmsm ashpublications.org/bloodadvances/…

14 clinically reported CRBN mutations were tested to determine their effect on response to IMiDs and CELMoDs in myeloma. 4 out of 14 could be overcome by CELMoDs. ashpublications.org/blood/article/…

I ran USAID health programs for the last 3 years. Trump’s 90 day Stop Work Order on foreign assistance does serious damage to the world and the US. Examples:🧵

Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma | Journal for ImmunoTherapy of Cancer ⁦MCW Cancer Center⁩ ⁦⁦Saurabh Chhabra⁩ ⁦Phari⁩ jitc.bmj.com/content/13/1/e…

Elon Musk, the richest guy in the world, is going after USAID, which feeds the poorest people in the world. Next, he’ll go after the programs that impact you: Medicaid, Medicare, community health centers, Pell Grants, affordable housing. We can stop him.

Another monoclonal gammopathy of clinical significance - this one thrombotic. Same story, different actors. #mmsm pubmed.ncbi.nlm.nih.gov/39938091/ . .

"It is a misnomer to call these funds indirect costs. They are essential to ...research. The environment in which research is conducted is highly specialized and costly. The government's share is not a give- away." Preach Dr. Holden Thorp, dormant account pubmed.ncbi.nlm.nih.gov/39932436/

NPCs in congress - spot on. What to do? Support campaign finance reform via Brennan Center so billionaires stay out of government. nytimes.com/2025/02/16/opi…

In case you didn’t know, this account is the PBM lobby. PBMs force patients to switch from generics to more expensive brand names because they get kickbacks (rebates) from the manufacturers. You can just assume that what PCMA supports is bad for healthcare.

Lack of RCT data on ASCT in AL Amyloidosis (+ ⬆️ TRM vs myeloma) makes decisions tough when VGPR/CR post-DaraVCd. This new TRM risk model by Eli Muchtar ⁦Mayo Amyloid⁩ will help us better weigh risks/benefits in clinic! ⁦⁦CAMP@CUIMC⁩ search.app/z6SjVNVXqTrmeX…

Creation of a mouse model is no small feat - congratulations! #amyloidosis #mmsm pubmed.ncbi.nlm.nih.gov/40148271/