“One of the greatest attributes of the HSG is the collegial approach to finding better HD treatments. HD Insights reflects this by amplifying the voices of clinicians, coordinators, healthcare workers & inspiring patient stories.” - Dr. Daniel Claassen bit.ly/3XBAGlE

Adenosine is important to your health. A recent study from the Hsu lab suggests that an adenosine transporter (ENT3) in microglia plays a protective role in Huntington’s disease. sciencedirect.com/science/articl…

The team, led by Drs. Yijuang Chern and Chun-Jung Lin, has developed a novel drug (J4) for the treatment of Alzheimer's disease and has received U.S. FDA approval to proceed to a Phase I clinical trial. (Contact: Ms. Jean Wu, [email protected]) biotrec.sinica.edu.tw/posts/184326

This review delves into the intricate details of glucose metabolism variances between neurons and glial cells in Huntington's disease, shedding light on their impact on disease progression. sciencedirect.com/science/articl… digital, ibms

Our recent findings highlights the potential involvement of the adiponectin-AMPK-TDP-43 axis in the dysregulated energy balance observed in ALS (sciencedirect.com/science/articl…). Alex Solleiro, fabianodasilvafilho, @AMPK

First-in-Human Dose! Exciting milestone—our Alzheimer’s drug candidate, J4, was administered to humans for the first time this morning. Grateful for the dedication of our team and partners in advancing this research. ＠Alzheimer's disease AcademiaSinica

We uncover an ENT2–inosine–PNP axis that sustains astrocytic ATP production. Loss of ENT2 disrupts purine metabolism, and amplifies inflammatory astrocyte reactivity, linking metabolic regulation to neuroinflammation. (sciencedirect.com/science/articl…) #Astrocyte #Neuroinflammation

J4, a first-in-class ENT1 modulator, restores brain energy metabolism and cognition in models of AD, offering a novel, metabolism-driven therapeutic strategy. (pmc.ncbi.nlm.nih.gov/articles/PMC12…) #Alzheimers #Neuroscience #DrugDiscovery #Metabolism