
Eddie Cliff
@eddie_cliff
haematology registrar | ex-@harvardmed @PORTAL_research | evidence-based medicine & policy | lymphoma | myeloma | Fulbright | writer | co-host @BloodCancerTalk
ID: 74081884
http://edwardcliff.com 14-09-2009 05:25:57
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Important context for anyone watching the STARGLO ODAC or listening to our Blood Cancer Talks discussion about it in terms of the FDA’s motivation

Delighted to share our manuscript from The Lancet Haematology Commission on Adverse Events We focus on optimising assessment of toxicity and tolerability in patients receiving novel therapies Led by the fab Paul Bröckelmann thelancet.com/journals/lanha… #lymsm Florian Simon Gloria Iacoboni

Beyond maximum grade: tolerability of immunotherapies, cellular therapies, and targeted agents in haematological malignancies - The Lancet Haematology Mohamad Mohty Eddie Cliff et al. thelancet.com/journals/lanha…


4/ Assessing adverse events and tolerability with immunotherapy which poses special challenges. Gita Thanarajasingam Mohamad Mohty marivi mateos Surbhi Sidana, MD The Lancet Haematology thelancet.com/journals/lanha…

🧵1/ Our paper is out! A new study from the iStopMM team in JAMA Oncology shows how revising free light chain (FLC) reference intervals can reduce false positives for light chain MGUS (LC-MGUS). Let’s break it down 👇 jamanetwork.com/journals/jamao…


So what steps can trialists, regulators, journals, editors, reviewers, sponsors & academics take to improve toxicity reporting + identification? 👇check out this figure from our The Lancet Haematology adverse event commission thelancet.com/journals/lanha… Surbhi Sidana, MD Mohamad Mohty






“Clinically meaningful improvement in overall survival (albeit without reaching statistical significance)” Where are the editors?! Common Sense Oncology

Conclusions from Bv-CHEP for Adult T Cell Lymphoma/Leukemia 1. High ORR & CR 2. Good Long-term survival w AlloSCT in CR1 3. It is possible to do ATLL-specific trials in the US. We can do better. Let's keep trying. onlinelibrary.wiley.com/doi/10.1111/bj… HTLV Aware #HTLV #ATLL Boston Medical Center



