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Must read! How a math model can predict the role of enhancers in gene network

New on the Node - Precision by design: Setting boundaries in patterning Edgar Herrera Delgado looks back on a theoretical-experimental collaboration that gave insights into the robustness of neural tube patterning #BehindThePaper #DevBio thenode.biologists.com/precision-by-d…

Our latest: Quantifying Waddington’s landscape Theory & xpts to construct dynamical models of differentiation: - makes testable quantitative predictions - reveals two fundamental cell decision mechanisms - generally applicable to wide range of systems biorxiv.org/content/10.110…

We are thrilled that our paper with the Schwille lab is now online in Nature Physics rdcu.be/ch6JR. Below is a brief summary of this joint experimental and theoretical work by the two first authors Beatrice Ramm and Andriy Goychuk 👇

New preprint! As a synthetic dev biologist, I always wanted to manipulate the shape of organoids. We developed an optogenetic tool to induce apical constriction in mammalian cells. Illumination of neural organoids caused shrinkage of the apical lumen. 1/ doi.org/10.1101/2021.0…

Our single-celled embryo study is now out eLife - the journal! Phenotypes are spectacular and images are pretty. Check it out! elifesciences.org/articles/68536

So happy to see our myosin mutants published in eLife - the journal after a very constructive review process with Review Commons! elifesciences.org/articles/68536

Our perspective on embryoids is out. We discuss the concept of "guided self-organization" and propose a way to study it. sciencedirect.com/science/articl…

New lab pic in the streets of #Paris😊 #100AnsCurie

Cleavage stages: 2 days without much going on, as far as morphogenesis is concerned. Cells must be pretty quiet, right? Well, actually it depends on how fast you're imaging! Here is the latest preprint from the lab with Özge Özgüç! biorxiv.org/content/10.110…

📢 We are looking for a #postdoc to join us Institut Curie in 2022! Please RT

There's apparently a sweet spot for explanation. A senior PI at a famous department said to me once: "the 1st part of your talk, showing the amazing things bioelectricity does in the body - I loved it! But then you showed the mechanism, turns out it's just physics :-(" 1/n

Interested in understanding how the amazing diversity of neurons in the nervous system emerges during development? 1 week left to apply for a PhD position in the lab of Andreas Sagner at FAU Erlangen-Nbg! tinyurl.com/5an4ruvx

Our latest: Quantifying Waddington Landscapes * Constructed dynamical models of ES cell differentiation from data * Identified 2 fundamentally distinct mechanisms of binary decisions * Models make quantitative predictions & generally applicable sciencedirect.com/science/articl…

Happy to see this piece out, we have covered (to our knowledge) all theoretical approaches to understanding preimplantation development. We discuss how modelling has provided concrete insights to the field, and look forward to exciting advances ahead! Jean-Léon Maître Cells & Development

Do you have a background in physics, mathematics or computer science and want to move to Spain☀️? If your are excited about self-organization and non-equilibrium thermodynamics apply for this scholarship to join our lab. Deadline 27-01-2022, more info here tinyurl.com/2a2mh954

🧑‍🔬Behind every great image, there are great scientists. Let us showcase the cameramen & camerawomen from @cellworlds_off ➡️ Jean-Léon Maître Özge Özgüç Markus Schliffka Edgar Herrera Delgado and others from Institut Curie CNRS 🌍 🔍Look for them : youtu.be/TR3tXKHE6-A

Our updated study of how SOX2 levels direct the WNT response of embryonic progenitors is now out! nature.com/articles/s4155… It was quite a puzzle to unpick – hopefully this thread helps to show why we found it so intriguing.

🚨🚨🚨 Interested in how embryos shape themselves?? We are looking for a #postdoc to join us Institut Curie in #Paris Please RT!

Our article "The Clock and Wavefront Self-Organizing model recreates the dynamics of mouse somitogenesis in vivo and in vitro" is out in Development 🥳 Discover how the Sevilletor equation can self-organize to make somitogenesis waves! #SelfOrganization journals.biologists.com/dev/article/15…