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CXCL13 shows up prominently in T cells in autoimmune tissues and tumors. Human Tfh and Tph cells produce lots of CXCL13, yet its regulation is pretty unclear. With beautiful CRISPR screens by Jaehyuk Choi, Calvin Law, we found a few key factors... nature.com/articles/s4158…

authors.elsevier.com/a/1jPbDL7PXqQnz links to a free download of our review in Cell for the next 50 days

I highly recommend this leadership & management training program for postdocs & junior faculty!

Have you wondered how Yamanaka found the 4-gene combination to transform somatic cells to stem cells? The # of possibilities are greater than - 20,000^4. I did this yesterday & read the original paper. What a journey & pure joy it was! Here’s how he did it. ⌛️

Finally out today! Very proud of this story: Innate immune memory after Stroke drives remote organ pathology This study was led by superstar-postdoc Alba Simats and X-less Sijia Zhang. Cell cell.com/cell/fulltext/…

1. Introducing a new thread: super basic lung pathology for PGY1s, with arrows. If you are a PGY1, leave a comment and I will tag you in a future post. A hamartoma is a disorganized mix of overgrown normal tissues (in their normal location) that creates a mass. Good news: they

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus - published now in Nature Communications Brigham and Women’s Research nature.com/articles/s4146…

Our latest study investigating risk factors for RA-ILD subtypes, led by Dr Gregory McDermott We systematically identified/subtyped all RA-ILD cases and RA-noILD controls in the Brigham and Women's Hospital RA Sequential Study and Mass General Brigham Biobank (n=3328) acrjournals.onlinelibrary.wiley.com/doi/10.1002/ac…

Our review paper led by Alene Saavedra, outlining several nuances that emerged for RA-ILD treatment in the recent ACR/CHEST guideline - in particular AZA and MMF We also review all trial evidence - only 3 RCTs (n=217 total!) have enrolled RA-ILD pts! link.springer.com/article/10.100…

Moving to edykimlab.bsky.social

Diverse natural killer T cells regulate innate immunity to improve neurological outcomes and survival after cardiac arrest Science Translational Medicine Edy Kim science.org/doi/10.1126/sc…

In a new study published in Science Translational Medicine, researchers from Brigham and Women’s Anesthesiology Mass General Anesthesia and colleagues found new insights into preventing brain injury after cardiac arrest. Read more: massgeneralbrigham.org/en/about/newsr… Edy Kim Fumito Ichinose doi.org/10.1126/scitra…