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As my group is slowly approaching size > 1, it's time for the new lab website: volkovlab.com. Will be soon looking for a postdoc and a technician (both funded by Biotechnology and Biological Sciences Research for 3 years). While the HR approve the official ads, feel free to reach out! RT is highly appreciated

RIP ESMFold server 😢 (anyone has extra storage to archive all the predicted structures and pretrained models before @MetaAI pulls the plug)?

Towards unraveling the origins of eukaryotic nuclear genome organization dlvr.it/StQQch

Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages | Nature Communications. ⁦Zeeshan⁩ ⁦Eelco Tromer⁩ ⁦Iva Tolić⁩ ⁦Karine Le Roch⁩⁦@BrochetLab⁩ nature.com/articles/s4146…

EvoDiff combines evolutionary-scale data with diffusion models for controllable protein sequence generation. In addition to generating plausible proteins, we can scaffold structural motifs in sequence space! Preprint: biorxiv.org/cgi/content/sh… Code: github.com/microsoft/evod…

Wu, Kops et al. UMC Utrecht Oncode Institute show that the mitotic #kinesin CENP-E promotes full expansion of the outer layer of the #kinetochore known as the fibrous corona independent of its motor activity. bit.ly/3FLQKtR #CellDivision #mitosis

Please share and/or apply!

END-OF-THE-YEAR-PREPRINT 🎄 We took a deep dive into the characteristics and dynamics of DNA loop extrusion by the eukaryotic SMC complexes – with some unexpected findings. Get comfy with your Glühwein and have a read... Thread below /1 📜Manuscript: t.ly/uFuPK

Happy to share our new study on the role of Plasmodium NEK1 in MTOC organization during male gamete formation. Thanks to fantastic collaborators @BrochetLab ; Eelco Tromer; Tony Holder; David Ferguson; Pathogens@KAUST; and Rita Tewari biorxiv.org/content/10.110…

And now (finally) published in EMBO journal! Thanks to CaL Milano for all the hard work bringing this together! embopress.org/doi/full/10.10…

We’re hiring - for anyone interested in mixing evolution with cell biology, I promise the #DeyLab has something for you - from cytoskeletal dynamics in weird protists sampled directly from the ocean to mitotic rewiring in engineered, lab evolved yeasts evonuclab.org

Looking for a PhD student to join my group studying bacterial virulence factors using cryo-EM, advanced biochemistry, and molecular biology. Modern environment, amazing colleagues, and a lively city in the Top of the Netherlands! Apply: rug.nl/about-ug/work-…

Hey. You folks like kinases, right? Check out our latest preprint on the evolution and specificity of effector kinases for P. falciparum. Among many findings, we see that P. falciparum has a bona fide tyrosine kinase (!) and that this evolved recently from an S/T ancestor (1/5).

Very inappropriate seq-struc analysis: Hence, conclusions presented here are questionable. 1st, there is no relationship between the RNase H fold endonuclease of the phage terminase& Colicin E5. 2nd the predicted functional residues are irrelevant science.org/doi/10.1126/sc…

1/n My postdoc work on the evolution of mitosis in Ichthyosporea Gautam Dey Omaya Dudin🍉¦ 🦠¦🔬¦ @SchwabYannick groups is out nature shorturl.at/KPRQw Art by Nirupa Rao contrast fungal-like closed with animal-like open mitosis. Why do cells carry out mitosis in different ways?

A new collaborative study by EMBL & EPFL scientists shows the way animals do cell division may have evolved long before animals did. The study suggests different modes of mitosis may be linked to different life cycles in certain marine protists. embl.org/news/science-t…

Congrats Hiral Shah with this elegant study - curious to hear where you go next!

We are excited to share our new findings on the NEK1 kinase in male gamete formation and kinetochore attachment in Plasmodium. We dedicate this paper to Professor Andrew Fry (1966-2024). Great collaborations. With Mathieu Brochet, Eelco Tromer Zeeshan PLOS Biology

Check out this preprint from Ben Jenkins et al! Genes acquired through HGT enable Paramecium to control its algal symbionts through a complex network of glycan sensing 🦠 Congratulations to all authors on this exciting discovery 🎉

In eLife - the journal: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei doi.org/10.7554/eLife.…. Out today. If you are at @biomalpar then happy to show the poster on it.