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In this study, Eleonora Porcu, Zoltán Kutalik and colleagues propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects between gene expression and complex traits. Find out more here: go.nature.com/2Y3bMli

We followed the classical cascade of methylation -> Gene expression -> protein levels -> complex traits and found several surprises... Detective work spearheaded by Marie Sadler & crucial support from Chiara Auwerx Eleonora Porcu biorxiv.org/content/10.110…

I could not recommend it more strongly! Just left the group and I'd apply again 1,000 times to join Zoltán Kutalik group! Amazing supervisor, amazing group, amazing environment. You have all the ingredients to do great science! Don't miss this opportunity!

Our new study on parent-of-origin (PofO) effects in the UK Biobank is now on bioRxiv ! Come and read how we inferred the PofO for more than 26k individuals and how this allowed us to discover 101 PofO effects. biorxiv.org/content/10.110…

New! Chiara Auwerx et al. explore the impact of CNVs on complex human traits Université de Lausanne bit.ly/3IBlrBF

Excited to have my 1st first author paper out in AJHG! 🤩 We explored the role of individual #CNVs and their burden in complex traits using UK Biobank and Estonian Biobank data. Summary of findings 👉🏻 tinyurl.com/5n8kpwva. Full text in #OpenAccess 👉🏻 doi.org/10.1016/j.ajhg….

🤩🤩Amazing work done by Jenny Sjaarda and Zoltán Kutalik using MR to investigate couple phenotypic similarity and distinguish causal and confounding effects 👇🏻

Come work with us on translational genomics: bioinformatician & data scientist positions at CHUV / Centre hospitalier universitaire vaudois precision medicine unit precisionmed_chuv. Enthusiasm, skills, and some French required... recrutement.chuv.ch/vacancy/bioinf… recrutement.chuv.ch/vacancy/specia…

🔔New pre-print out!!! With Chiara Auwerx Marie Sadler Alexandre Reymond and Zoltán Kutalik we combined eQTL, mQTL and GWAS data in a multi-omics Mendelian Randomization approach to identify metabolites mediating transcript-trait associations. biorxiv.org/content/10.110…

Super happy to join the #ESHG2022 in Vienna!! We are back with in person conferences and it’s really exciting!! European Society of Human Genetics (ESHG)

Waiting forward to discussing with you about PRS in cardiovascular diseases! With Jacques Fellay we propose a metaPRS to predict the risk of sudden cardiac arrest in CAD patients! Come to discuss with me today at 1pm - poster P25.001.A #eshg2022

📢📢new pre-print out!!! With Jacques Fellay precisionmed_chuv we developed a #PRS combining multiple cardiac risk factors to predict the risk of sudden cardiac arrest in patients affected by coronary artery disease medrxiv.org/content/10.110…

A polygenic risk score to predict sudden cardiac arrest in patients with coronary artery disease medrxiv.org/content/10.110…

I will be always grateful for the opportunity I had to do my postdoc in Zoltán Kutalik lab! Amazing supervisor, great colleagues, exciting science…you cannot ask more🤩 Strongly recommended!!

Excited to share that our paper about DNAm mediation through transcript levels is now published Nature Communications! nature.com/articles/s4146… Very grateful to all co-authors Chiara Auwerx Kaido Lepik Eleonora Porcu Zoltán Kutalik for their precious contribution! #omics #GWAS #MendelianRandomization

I strongly recommend all early career bioinformaticians to apply for this amazing opportunity!!