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Proud and humbled to share our recent paper on Nature Communications!It's such a thrill to see the paper finally out! Huge thanks to my PI Paola Romagnani and to Elena Lazzeri How does the kidney adapt to AKI? #polyploidy #AKI #CKD 👇 nature.com/articles/s4146…

Polyploid tubular epithelial cells become senescent in the long run driving AKI-CKD progression.. however blocking continuos tubular cells polyploidization through YAP1 inhibition or senolytic therapy is able to prevent CKD progression 👇👇👇 nature.com/articles/s4146…

Single Cell-RNAseq on mouse kidneys after AKI and in vitro human cell culture showed that polyploidization of tubular epithelial cells depend on YAP1 activation

Polyploid tubular cells save the patient life early in AKI recovering function by hypertrophy but they turn senescent on the long run promoting kidney fibrosis and CKD. nature.com/articles/s4146…

The good new is that we can prevent CKD development after AKI by blocking repeated polyploidization of tubular cells and avoiding that these cells become senescent and drive CKD nature.com/articles/s4146…

Un team di ricerca internazionale, coordinato da Paola Romagnani, docente #Unifi di Nefrologia, ha messo a punto una nuova terapia che previene lo sviluppo di malattia renale cronica legata al danno renale acuto Lo studio è su Nature Communications 👉 bit.ly/3rDWnTK #ricercaUnifi

Paola Romagnani sharing our experience on genetic testing for kidney diseases in daily clinical practice at #KidneyWk. Thanks to all the #nephrogenetics people who made this possible.

Excited to share our last work on JASN_News. Genetic diagnosis of kidney diseases is feasible, cost-saving and extremely important for our patients. Thanks to Paola Romagnani Luigi Cirillo Valentina Raglianti Gianmarco Lugli Viviana Palazzo Samuela Landini LetiziaDeChiara

Using our diagnostic algorithm we changed the initial clinical diagnosis in 1/5 of patients with genetic kidney diseases. Reported in our new study in JASN bit.ly/JASN076

Polyploidy is indeed everywhere! Yves van der peer giving a riveting keynote talk at #polyploidy2023

Starting the day with polyploidy wound healing by Vicki Losick #Polyploidy2023

letizia de chiara expressing immense relief that people at #polyploidy2023 believe things become polyploid while introducing her talk!

FoxLabDuke wrapping up #polyploidy2023 with some thought provoking messages on how to think about polyploidy moving forward: Pay attention to ploidy levels, ploidy specific molecules, and what conditions favour polyploidy

International Polyploidy Conference..Polyploidy Across the Tree of Life. This stimulating meeting came to a close today...with the exciting announcement that the next conference will be in Wageningen, Netherlands in 3 years!!!!

Brian Calvi showed us some amazing examples of induced endocycling cells 🤯 #Polyploidy2023

On the way back from a great conference!! It was amazing to meet so many polyploidy enthusiastic!! Thanks for the opportunity to present our work!! Elena Lazzeri #Polyploidy2023

Finally out! New proposed classification of glomerulonephritis focused on etiology, activity and chronicity to optimize patient management. ⁦Hans-Joachim Anders⁩ ⁦⁦Kitching Laboratory⁩ and Nelson Leung academic.oup.com/ndt/advance-ar…

From plants to animals, polyploidy is the fastest way for adaptation to stress selected by evolution. The kidney tubule adapts to stress by polyploidy, too. We discuss evidences and consequences of this new concept in our new KI review doi.org/10.1016/j.kint…

In the kidney polyploid cells are frequently mononucleated. If only DNA content is measured they can be mistaken as G2/M cells. With cycle markers such as PCNA or Ki67 they may seem proliferating cells. Particular techniques are needed to detect them doi.org/10.1016/j.kint…

The impact of polyploid tubular cells in the kidney is still underestimated. 👇Check out our new Review in KI where we discuss the central role of this adaptive response in the kidney tubule Paola Romagnani Elena Lazzeri doi.org/10.1016/j.kint…