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The fact that the loop is not immediately disturbed after CTCF/Cohesin depletion makes total sense, because chromatin is not at a thermodynamic equilibrium. Significant time is needed to "relax" an existing chromatin loop, even if loop ends are no longer forced to stay together

Elena Pugacheva Thank you for pointing out this, it's an excellent paper! It seems indeed the effect of CTCF mutation is bigger than the effect of CTCF acute depletion, and the latter one is time-dependent.

We are looking for a new bio-computational PhD Fellow capable to analyze at least some of many diverse "omics" NG-Seq datasets obtained with genome-edited mouse strains & human cell lines designed to study a unique type of site-specific epigenetic marks: training.nih.gov/postdoc_jobs_n…

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Happy to share! Our latest publication in Genome Biology unveils how BORIS/CTCFL epigenetically reprograms transcriptionally inactive intronic CTCF sites into alternative promoters: genomebiology.biomedcentral.com/articles/10.11…

Check out the latest from Michele on the disease named after him (YY1 mutations --> Gabriele-de Vries syndrome). Michele is on the job market - do not miss out :) K99: reporter.nih.gov/search/832CJGw… Paper: science.org/doi/full/10.11…

👁️ Systematic identification of interchromosomal interaction networks supports the existence of specialized RNA factories Borislav Hristov, William Stafford Noble & Alessandro Bertero | Genome Res (Sep 25, 2024) genome.cshlp.org/content/early/…