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#Precancerous Cells Initiate #Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity: aacrjournals.org/cancerdiscover…

From the July issue: Activated T Cells Break Tumor Immunosuppression by Macrophage Re-education brnw.ch/21wUj8N By Rosa Trotta, Silvia Rivis, Shikang Zhao, Mazzone Lab, and colleagues at @VIB KU Leuven

Activated T Cells Break Tumor Immunosuppression by Macrophage Reeducation ⁦Cancer Discovery⁩ aacrjournals.org/cancerdiscover…

Trends in Cancer Incidence and Mortality Rates in Early-Onset and Older-Onset Age Groups in the United States, 2010–2019 ⁦Cancer Discovery⁩ aacrjournals.org/cancerdiscover…

Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations | Cancer Discovery | American Association for Cancer Research aacrjournals.org/cancerdiscover…

From the July issue: Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response brnw.ch/21wUkWx By Alexandra Redding, Elda Grabocka, and colleagues at Sidney Kimmel Comprehensive Cancer Center

It's that time of year - roll call for all new #cancer PIs who just started or who are about to start their labs! Please say hi and what you work on so I can follow you if I don't already! 😃 #NewPI

Elizabeth McKenna Hi Elizabeth McKenna! New PI from MD Anderson to the University of Colorado studying therapeutic resistance in lung cancer.

Elizabeth McKenna Hello Elizabeth McKenna! I’m starting my lab at UCLA Bioengineering this Fall working on AI-generated proteins to understand and tackle cancer signaling. I’m more active on Bluesky btw (same username).

Elizabeth McKenna Hi

By @Pezcoller–AACR Award for Extraordinary Achievement in Cancer Research winner Douglas Hanahan: HPV16-Expressing Tumors Release Multiple IL-1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Vaccine Efficacy brnw.ch/21wUmNn

🧠 How does glioblastoma begin? This groundbreaking study uncovers precancerous cells as the seeds of GBM evolution—fueling heterogeneity and revealing new therapeutic targets. A must-read for neuro-oncology researchers. #Glioblastoma #CancerEvolution doi.org/10.1158/2159-8…

From the July issue: Requirement for Cyclin D1 Underlies Cell Autonomous HIF2-Dependence in Kidney Cancer brnw.ch/21wUoBl By Nitin Shirole, KaelinLab, and colleagues at Dana-Farber

For a few individuals, scientists found genetic material from cancerous tumors in blood samples taken years before they were diagnosed through traditional methods. bit.ly/3ILO1Fy

From the July issue: RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression brnw.ch/21wUqF2 By Augusto Bleve, Martina Incerti, Antonio Sica, and colleagues

Congrats on Mayo Clinic Urology published study led by Drs Veronica R Bravo and Josep Domingo-Domenech discover that nucleoplasm-residing nucleoporins drive #ProstateCancer progression & immune evasion by switching on oncogenic signaling from deep within the nucleus! vist.ly/3z88z

Congratulations to first authors Kirthika, VJ and Peiyao 👏 👏 👏! Great collaborative effort with Zhu Lab and Veronica R Bravo labs. Also thanks to reviewers and editors Cancer Discovery for positive and constructive feedback.

Elizabeth McKenna #newPI from NIH to start the Cancer Prevention & Tumor Evolution lab Nemours Children's Health! We are interested in discovering & validating #biomarkers in cancer predispositions (#EndNF) as well as using #liquidbx in clinical & preclinical models of #childhoodcancer for adaptive risk modeling