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After a massive team effort leaded by the incomparable Nicola Festuccia I am really happy to share our freshly published Science Magazine ms where we elevate Nr5a2 to the top of gene regulation in the morula. 🔥🔥🔥 Take a look at Nicola's description 👇! science.org/doi/10.1126/sc…

1 week left to apply to the open-rank faculty search for the UCSF dept. of Biochemistry & Biophysics All area of fundamental biology are welcome Reach out if you have any questions

📢 New preprint from the lab! CRISPR-screening wizard 🧙 🧬 Till Schwämmle figured out how different signals 🚦 are integrated at the Xist locus. See his tweetorial below. biorxiv.org/cgi/content/sh…

We Yin Shen are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. biorxiv.org/content/10.110… 1/20

CTCF, just like any transcription factor, binds its target sites on and off. Turns out considering this dynamic is essential to explain chromosome folding patterns from Hi-C and microscopy, and how they rearrange upon tampering with cohesin. What an exciting manuscript! 👏

It’s a bit belated, but I am happy to share the latest work from our group, led by a very talented post doc in the lab, Tessa Popay Tessa Popay with great support from the 4D Nucleome consortium, Rita Allen, and the Pew Biomedical Scholars. biorxiv.org/content/10.110…

🎉Excited to finally share that our new work (previously bioRxiv) is now online at nature! A fantastic team effort with amazing collaborators. You can read the paper by using the following link: rdcu.be/dXQs7 A thread 🧵/1 nature.com/articles/s4158…

In short, we investigated the impact of DNA methylation (5-methyl-CpG) on 1. CTCF promoter-enhancer looping and 2. Polycomb-associated H3K27me3. To our surprise, we found both regulatory mechanisms converge to modulate the expression of Zdbf2, Maxim Greenberg ‘s favourite gene.

I’m excited to share the first preprint out of the Altemose Lab! This stems from a heroic effort by Dr. Matt Franklin Matt Franklin (who's on the job market!), who made surprising discoveries regarding some of the most mysterious regions of the genome. biorxiv.org/content/10.110…

‘Human Peoples’ is out Penguin Books A genetic journey through how migrations, admixture (among humans and with Neanderthals and Denisovans), and adaptations to environmental pressures (climate, nutrition, pathogens) shaped our physiology and health today. amazon.co.uk/Human-Peoples-…

Thrilled to share our new preprint, 'A genome wide code to define cell-type specific CTCF binding and chromatin organization'. biorxiv.org/content/10.110…

Target gene responses differ when transcription factor levels are acutely decreased by nuclear export versus degradation Read this Research Article by James McGehee and Angelike Stathopoulos Angelike Stathopoulos Stathopoulos Lab: journals.biologists.com/dev/article/15…

Ecstatic to share the first story from my post-doc, co-led with Megan Ostrowski, out now in final form (cell.com/cell/fulltext/…)!

@elphegenoralab.bsky.social