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Ivermectin: the largest randomized, double-blind trial yet conducted, with early treatment, indicates there is no difference compared with placebo. It doesn't work. Period. nejm.org/doi/full/10.10… just published NEJM

I refuse to defend my thesis. It's never going to make it in this world if it doesn't learn to fight for itself

A year ago, a non-academic friend listened to a talk I gave. I thought it went great. My friend disagreed. She said that academics are experts at making interesting stuff boring—and that we should all take a speech class. So I did. And here are 6 most useful things I learned.

New study reveals insights into how early immune response defines severity of COVID-19 eurekalert.org/news-releases/… Congratulations to everyone involved, in particular @FDouam and Devin Kenney! NEIDL Princeton MolBio Princeton Innovation

Did every princeton student really just know that Robert Downey Jr, Matt Damon and Emily Blunt are all chilling on campus making a movie right now? I'm really the only person who didn't know? 😐 seriously?

Just an FYI - it costs you nothing to reference papers in your field in your own publications. It doesn't lessen the impact or the worth of your work to acknowledge others also did impactful work. Don't be that person. Reference generously.

Good graphic for how Omicron (and its various BA. family lineages) gets into cells, which differs from prior variants. A nice explainer for its hyper-contagiousness scientificamerican.com/article/omicro… Scientific American by Megan Scudellari and @FalconieriV

Very excited that my work on the HBV genotypes is published JHEP Reports Many thanks to my mentor Alexander Ploss and everyone in Plosslab. Special thanks to Robbie LeDesma Emily Mesev for their revisions. Thanks Glenn for the mouse gavage help and our collaborators in this work.

Congratulations ⁦Emily Mesev⁩ & thank you for presenting our joint work with ⁦jared toettcher⁩ at #cytokines2022 and #ilc4 ⁦#ifnl2022 ICIS 🦋 @cytokinesociety.bsky.social⁩ in beautiful #hawaii We are proud of you. Don’t miss ⁦Emily Mesev ‘s talk on Sept. 24! ⁩ Princeton MolBio⁩

Here we are, the in-person part of the #IFNL22 meeting 🌴🌴🌴🤗! ICIS 🦋 @cytokinesociety.bsky.social, Ivan Zanoni, Dr. Deanna Santer, Juan L. Mendoza, Steeve Boulant, Charlotte Odendall Megan Stanifer, @RamLabUW, Vangelis Andreakos, BaldridgeLab and many more!!

While both natural immunity and mRNA vaccines build protection against SARS-CoV-2, the vaccines side-step the development of self-attacking antibodies that frequently occur in COVID-19 patients. Yale School of Medicine Prof. Akiko Iwasaki #Yale medicine.yale.edu/news-article/v…

It's official! Successfully defended my PhD in Molecular Biology at Princeton yesterday! Huge thanks to my two fantastic advisors Alexander Ploss and jared toettcher and my amazing labs who've supported me these last 6 years (and made me the best PhD cake ever). 🥳

Some super cool tool development by @PayamFarahani and jared toettcher!! Very glad I got to be part of this awesome project. Everyone should go read the reviewed paper!

hello world! new results (with jared toettcher): tinyurl.com/3595banh Stem cells can self-organize morphogenesis in vitro w/o spatial patterning cues. But how? We programmed cells to record their signaling histories to map symmetry breaking during gastruloid morphogenesis (1/n)

Preclinical experiments decipher how a protein promotes antibody responses through NF-kappaB signaling, scientists uncover the source of signaling strength from interferon receptors, and more in this week’s new issue of #ScienceSignaling. scim.ag/4pW

Incoming viral attack🗡️! Interferon receptors to the defense🛡️, but what exactly is going on inside and outside the cell membrane with Type I & Type III interferon receptors? For some answers, see this explainer of the Mesev, Toettcher, and Ploss paper: molbio.princeton.edu/news/2023/jak-…

Please check out our newest study deciphering diff. in signaling strength betw type I&III #interferon receptors science.org/doi/10.1126/sc… Outstanding work by Emily Mesev + fantastic collaboration with the terrific jared toettcher ! Thanks to everyone involved! Princeton MolBio Princeton University

And in an accompanying study, Emily used her synthetic receptors to uncover some interesting differences in JAK requirements for Type I and III interferon receptors! liebertpub.com/doi/full/10.10…

Why do type I #interferon receptors signal more strongly than type III receptors? The Alexander Ploss and jared toettcher lab find that type I receptors harbor a short kinase-binding motif that correlates with greater signaling strength. Princeton MolBio #immunology science.org/doi/10.1126/sc…