✨ Small rings, significant impact! We’re thrilled to present the latest research from our Enamine scientists: “Synthesis and Physicochemical Properties of Functionalized cis‑2-((Fluoro)alkyl)cyclobutanes” by Anton Chernykh et al. This work introduces a scalable and versatile

To create Enamine CNS-targeted library that supports the discovery of new CNS drugs, we applied versatile selection approaches, focusing on molecular properties and structural features preferable for BBB permeability. Enamine CNS Library for hit discovery offers several

Molecule of the week EN300-52660942 More details: bit.ly/3HJPT13 Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery

Join us at "Data & Drinks CT – Eliminating Data Silos in Biotech". Connect with industry peers, swap lessons, and explore collaborations over wine, beer, and appetizers. Enjoy a 30-minute actionable panel discussion with experts. No long-winded presentations, just real-world

Meet a refined spirocyclic amino-oxetane: 4-oxaspiro[2.3]hexan-6-amine – a compact, conformationally restricted building block with exceptional purity (just look at the spectrum!). #Enamine #nmr #nmrchat #chemistry

Introducing bridged morpholines can help adjust the pharmacological profile, including metabolic clearance, solubility, and permeability: bit.ly/3I12X1P Try our bridged morpholines in your research!

We are excited to share an update to Enamine REAL Space, the world's largest searchable chemical space of REadily AccessibLe molecules. With this update, the REAL Space now includes 76.9 billion individual molecules, which is 12 billion more than in the previous version. The

Molecule of the week EN300-28263630 More details: bit.ly/4kcoMJg Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery

Proud to contribute to mechanistic insights via CADD! Our team recently contributed to a study (pubmed.ncbi.nlm.nih.gov/40517317/) exploring the editing mechanisms of Thermus thermophilus leucyl-tRNA synthetase (LeuRS). Using advanced CADD approaches, including quantum mechanical

From day one, Enamine has been a purely scientifically-driven company. For more than 30 years, our scientists have co-authored an impressive number of publications, making significant contributions to the global research community.   Since 2003, the number of publications

Please welcome Ivan Mazurenko - the chemist behind the molecule of this week. Congratulations! 👏 bit.ly/40COJL9 Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery

Spiroalkyl groups increase volume and lipophilicity of bioactive molecules while being less prone to metabolic clearance. The diversity of spirocycles is exemplified here by a collection of over 200 amines: bit.ly/4eQHHZn Try our spiroalkyl amines in your research!

Qanatpharma (QP), Zuse Institute Berlin (ZIB), Enamine, and Proteros biostructures are excited to announce the launch of a research collaboration to accelerate the discovery of novel therapeutics targeting cerebral perfusion deficits associated with subarachnoid hemorrhage (SAH).

Molecule of the week EN300-52797884 More details: bit.ly/4eBzQOY Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery

Together with Chemspace, we are excited to announce a strategic collaboration with Orogen Therapeutics to enable unique REAL-driven DNA-encoded small molecule libraries. By combining Chemspace’s cheminformatics and synthetic capabilities, Enamine’s REAL design principles, and

Molecule of the week EN300-53023792 More details: bit.ly/4kULupW Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery

Check out the recent paper: “Machine Learning-Based Retention Time Prediction Tool for Routine LC-MS Data Analysis”, co-authored by Sofiia Dymura, Oleksandr Viniichuk, Kostiantyn Melnykov, Dmytro Radchenko, and Oleksandr Grygorenko (Oleksandr Grygorenko 🇺🇦). This study presents the

Researchers from Bayer AG have recently initiated clinical trials for a dual thrombin inhibitor designed with a metabolic soft spot based on a diaminopropionic acid building block: bit.ly/4nPD0CP Try our diaminopropionic acid-based molecules in your research!