🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Oncocytic thyroid tumors are packed with mitochondria, but what do we know about their proteome? Herein, authors link dysregulated mitochondrial proteins - like overexpressed IDH2 - to tumor aggressiveness. And we thought the TCA cycle was a pheo thing! link.springer.com/article/10.100…

Study from 🇸🇪 find TERTp mutations in 12% of minimally invasive FTCs. More common in older patients, these (often subclonal) events didn’t impact outcome (yet) - but size alone may not tell the full story! C. Christofer Juhlin Vincenzo Condello link.springer.com/article/10.100…

Glucagonomas: rare pancreatic tumors causing a striking skin rash and packing molecular surprises. These large tumors were mostly grade 1, displayed MEN1, ATRX/DAXX mutations, and sometimes high tumor mutational burden - a potential treatment target. link.springer.com/article/10.100…

Our journal features two ground-breaking papers in which a molecular link between well-differentiated NETs and high-grade NECs is proposed, arguing that a subset of well-differentiated cases may be at risk of progression! link.springer.com/article/10.100… link.springer.com/article/10.100…

New study reveals that separately fixed thyroid tumor samples, including lymph node metastases, preserve DNA and RNA quality better than traditional methods - opening doors for more accurate genomic analysis and targeted therapies in thyroid cancer! link.springer.com/article/10.100…

New insights into functioning PanNETs! 🧬 ATRX/DAXX mutations & ALT are linked to aggressive behavior in insulinoma and other functioning tumors. These markers could serve as key prognostic indicators, enhancing diagnosis and treatment strategies. link.springer.com/article/10.100…

New study from C. Christofer Juhlin and Vincenzo Condello regarding RAI refractoriness in papillary thyroid carcinoma! By analyzing RNA-seq data, researchers found that ANO1 expression, along with histological subtypes, could serve as a predictor of iodine avidity. link.springer.com/article/10.100…

A study of pediatric papillary thyroid carcinoma in China reveals key genetic insights. RTK fusions, such as BEND7::ALK, DLG5::RET, and CCDC30::ROS1, are linked to aggressive tumor features and poor prognosis and may open up for therapeutic alternatives. link.springer.com/article/10.100…

TERT amplification correlates with vascular invasion and distant metastases in thyroid cancer, suggesting it may serve as a prognostic marker. The study emphasizes its significance in understanding tumor behavior and patient outcomes. bit.ly/4jlvbCj Endocrine Pathology

TERT amplification is linked to worse outcomes in thyroid cancer, including recurrence and survival in PTC. Found in 17–20% of tumors, it's more frequent in aggressive subtypes and metastatic cases. A potential new prognostic biomarker? link.springer.com/article/10.100…

Ectopic Cushing syndrome (ECS) is usually tied to neuroendocrine tumors (NET), not small cell lung cancers (SCLC). A deep dive into 205 cases and ACTH tests on 313 tumors reveals little support for SCLC causing ECS - many cases were reclassified as NET! link.springer.com/article/10.100…

Small tumors, big surprises! Non-functioning duodenal NETs may look quiet, but their hormone profiles speak volumes. Somatostatin and friends could be key to predicting aggressiveness - turns out, size isn’t everything! Read it now in Endocrine Pathology! link.springer.com/article/10.100…

ABCC3 marks the quiet zone! New study in Endocrine Pathology shows ABCC3 is absent in aldosterone-producing lesions and inversely linked to CYP11B2 - making it a promising marker to distinguish normal adrenal cortex from APAs. link.springer.com/article/10.100…

Take note: a true rarity just dropped in Endocrine Pathology! This case report details three synchronous, histologically distinct PitNETs in one patient - confirmed by epigenomic profiling. No hormonal symptoms. A must-read: link.springer.com/article/10.100…

🎉 Congratulations to our Editor-in-Chief, Dr. Ozgur Mete, on receiving the 2025 Springer Nature Editorial Contribution Award and Author Service Award! A well-deserved recognition of his leadership, dedication, and service to the endocrine pathology community. 👏🔬🧬

Pediatric DICER1-associated thyroid carcinomas may show a distinct tumor-in-tumor pattern with high-grade features and CHEK2 variants in addition to established atrophic changes. Findings may shed light on progression via the ATM-CHEK2-TP53 pathway! link.springer.com/article/10.100…

Silver‑based reticulin stains are revealing more in endocrine tumors - from pituitary to adrenal and neuroendocrine lesions. With AI and digital pathology stepping in, diagnostics are getting sharper. Want the full breakdown? Dive into this game‑changer! link.springer.com/article/10.100…

Big news! Endocrine Pathology now holds an Impact Factor of 14.7 - ranking us #2 out of 90 pathology journals. A huge thanks to our authors, reviewers, and readers. Submit your outstanding research and be part of the momentum!

We are very happy to announce Endocrine Pathology's IF is now 14.7. 2/90 Pathology. 7/191 Endocrinology & Metabolism. Congrats to the team and thanks for the hard work. Also thank you to the authors, reviewers and readers for your support.

Can AI help tackle the diagnostic challenges of NIFTP in thyroid pathology? A new study proposes a 3-stage deep learning pipeline - showing promise, but with key hurdles ahead. 🧠🔬 Read more in #endopath link.springer.com/article/10.100…