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Photodynamic therapy and priming allow the localized destruction of diseased cells. In their Review, Tayyaba Hasan, Huang-Chiao Huang et al outline the mechanisms and molecular engineering of PDT for the treatment of cancer HasanLab go.nature.com/45yAKqZ

Big day for the lab as our latest paper is out in Nature Chemical Biology Nature Chemical Biology on identifying the oxybipins as new OSBP inhibitors, as well as their mechanism of action and therapeutic applications! nature.com/articles/s4158… 1/n

Hybrids of macrolides and quinolones, called macrolones, can overcome macrolide-induced resistance through new interactions between the quinolone moiety and the ribosome and can concurrently inhibit both ribosome and DNA gyrase targets. Free to read link rdcu.be/dOzB8

Check out our paper: A Nanoencapsulated Ir(III)-Phthalocyanine| ACS Appl. Mater. Interfaces pubs.acs.org/doi/full/10.10… Great collaboration with Angela Sastre Santos & MarchanLab. Congrats to all co-authors Joaquin Bonelli Blasco Gloria Vigueras Eduardo Izquierdo García Pezhman Ashoo Enrique Ortega-Forte,...

Super happy to see my first ACS Applied Materials & Interfaces published. It is always a pleasure to work with all these amazing investigators. A nanoencapsulated Ir(III)-phthalocyanine conjugate as a biocompatible red-light-activated PDT agent with efficient performance under hypoxia 🙌🏼✨

Happy to see our work published today in ACS Publications. We engineered a light activatable nanomaterial with potent anticancer activity under hypoxia. Great collaborative effort. Congratulations! ➡️ pubs.acs.org/doi/10.1021/ac…

🚨#PhDPosition Alert! Passionate about #ChemBio and #MedChem? Got a strong background in 🧪 #OrganicChemistry? Join us at MarchanLab We offer a 4-year #PhD fellowship to develop🌟 light-activated drugs 💊 for cancer diagnosis & therapy. 🔬 #PDT #Metallodrugs #ScienceJobs

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

For readers interested in therapeutic strategies for cancer, this review in the August issue discusses the roles of reactive oxygen species (ROS) in cancer and the development of effective ROS-based cancer therapy bit.ly/3zCgglm rdcu.be/dQnC0

A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2 Nature Chemical Biology nature.com/articles/s4158…

So excited to to share our lab's photosensitizer proximity labeling platform, POCA, which combines Janelia Fluors (thanks @rhodamine110!) with HaloTag and cholesterol-based probes to define the intracellular cholesterol interacting proteome. Congrats to Andrew Becker and team!

science.org/doi/10.1126/sc…

Tartrazine dye can reversibly render a live mouse body transparent. It can modify the refractive index of the aqueous medium to match that of high-index cell components and allow visualisation of deep tissues an organs. science.org/doi/10.1126/sc…

Excited our final version of Christine Isadora Ng's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. Sarafan ChEM-H Stanford Chemistry nature.com/articles/s4158…

Check out our recent News & Views highlighting awesome new work from the Banik Lab (Steven Banik) on targeted protein localization! ✨✨ nature.com/articles/d4158…

Had fun testing the VR glasses for molecular visualization #EuropeanResearchersNight. Great job making science so interactive!

Takami Sho, Li Yu et al. Tsinghua University unveil migratory autolysosome disposal, a response to #lysosome damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring #autophagy machinery, SNARE proteins, and cell #migration. hubs.la/Q02Rwbhg0

This is great! NIAID News have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

Learn how proteins move from the ER to the Golgi via ER exit sites! Learn more at smart-biology.com #biology #science #3D #animation #EdTech

Glad to see our work "Achieving red-light anticancer PDT under hypoxia using Ir(III)-COUPY conjugates" in Inorg. Chem. Front. pubs.rsc.org/en/content/art… Great collaboration MarchanLab Santi Nonell Antonio Francés Marta Erminia Alberto Leitat Enrique Ortega-Forte Gloria Vigueras