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Key point: Cranial surgeries, acute care seizures, intracranial fragments, and traumatic hemorrhages were leading PTE predictors in this cohort. doi.org/10.1111/epi.18… #epilepsy #ILAE #LASSO #prognosticmodel #riskcalculator #seizure #TBI International League Against Epilepsy Wiley Neuro @epilepsiajourn

New Articles in Epilepsia - December 14, 2024 mailchi.mp/ilae/new-artic… #epilepsy #ILAE International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: Extracellular GABA levels exhibit a more rapid and severe deficit compared to Gad2 neuron responses amid PC-optokindling seizure events. doi.org/10.1111/epi.18… #epilepsy #ILAE #GABAsensor #Gad2neurons #seizures International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: Insulo-opercular FCD lesions can be categorized based on location and extent into insular, peri-insular, opercular, and complex types. doi.org/10.1111/epi.18… #epilepsy #ILAE #clusteranalysis #focalcortical dysplasia #SEEG International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: #LLMs are used to analyze #Reddit data, revealing unfiltered insights into #epilepsy patient concerns doi.org/10.1111/epi.18… #ILAE #ASM #forums #mentalhealth #peersupport #substanceuse #suicidality International League Against Epilepsy Wiley Neuro @epilepsiajourn #languagemodels

Key point: This is the first large-scale, preclinical, multi-center study on microRNA (miRNA) biomarkers in epilepsy. doi.org/10.1111/epi.18… #epilepsy #harmonization #lateralfluidpercussion #posttraumaticepilepsy #preclinical #vEEG International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: ASM-related complexity changes may serve as a biomarker to identify patients with TLE independent of interictal epileptiform discharges. doi.org/10.1111/epi.18… #epilepsy #ILAE #ASM #EEG #IEDs #temporallobeepilepsy International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: Our method independently identified clusters of waveforms consistent with epileptiform discharges and generalized paroxysmal fast activity. doi.org/10.1111/epi.18… #epilepsy #ILAE #IEDs #machinelearning #sleepspindle International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: A lifelong nutritional regimen enabled mice with lethal developmental and epileptic encephalopathy (DEE) to survive for more than 1 year. doi.org/10.1111/epi.18… #epilepsy #ILAE #migrationdefect #Nkx21 #parvalbumininterneuron International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: ES occurred in 32% of 260 neonates with HIE undergoing therapeutic hypothermia. doi.org/10.1111/epi.18… #Epilepsy #Ilae #EEGmonitoring #hypoxicischemicencephalopathy #neonatal #seizure #statusepilepticus International League Against Epilepsy Wiley Neuro @epilepsiajourn

Stereoelectroencephalographic thermocoagulation in FLNA-positive heterotopia: Is it an effective treatment? doi.org/10.1111/epi.18… #epilepsy #ILAE #FLNA gene #periventricularnodularheterotopia #SEEG #thermocoagulation International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: White matter architecture is altered at the very early stages in epilepsy, even before a diagnosis is made with standard criteria. doi.org/10.1111/epi.18… #epilepsy #Ilae #diffusionimaging #imagingbiomarkers #TBSS #seizures International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: TSPO maps show all seizure foci, suggesting that they may represent a global snapshot of interictal #neuroinflammation rather than the effects of a specific seizure type. doi.org/10.1111/epi.18… #epilepsy #ILAE #TSPOPET International League Against Epilepsy Wiley Neuro @epilepsiajourn

New Articles in Epilepsia - December 21, 2024 mailchi.mp/ilae/new-artic… #epilepsy #ILAE International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: Almost all trials in our study exhibited a lack of racial diversity among participants. doi.org/10.1111/epi.18… #epilepsy #ILAE #bias #healthequity #healthinequities #minoritygroups #racialgroups International League Against Epilepsy Wiley Neuro @epilepsiajourn

Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study doi.org/10.1111/epi.18… #epilepsy #cognition #olderadults #practicaljudgment International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: Free ASM, improved adherence, and access to second- and third-line ASMs were key contributors for seizure control. doi.org/10.1111/epi.18… #epilepsy #ILAE #antiseizuremedication #noddingsyndrome #onchocerciasis #subSaharanAfrica International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: Barriers to care limit or prevent people from receiving adequate care for specific conditions, including community-onset #pediatric status epilepticus. doi.org/10.1111/epi.18… #epilepsy #seizures #treatment #Statusepilepticus International League Against Epilepsy Wiley Neuro @epilepsiajourn

Key point: After therapeutic failure of SLAH, repeat temporal lobe surgery is possible but characterization of this is quite limited. doi.org/10.1111/epi.18… #epilepsy #ILAE #lobectomy #LITT #repeatsurgery #SLAH #temporallobeepilepsy International League Against Epilepsy Wiley Neuro @epilepsiajourn

New Articles in Epilepsia - December 28, 2024 mailchi.mp/ilae/new-artic… #epilepsy #ILAE International League Against Epilepsy Wiley Neuro @epilepsiajourn