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Key point: First published exome study in Nigerian children with early-onset epilepsy finds genetic diagnosis in up to 27%. doi.org/10.1002/epi4.1… #epilepsy #ILAE #DEE #geneticvariants #Nigeria #personalizedmedicine #wholeexomestudies International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Symptomatic VABAM is strongly associated with coadministration of hormonal therapy with vigabatrin. doi.org/10.1002/epi4.1… #epilepsy #ILAE International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Epilepsia Open - Recently published articles (November 24, 2024) mailchi.mp/ilae/epilepsia… #epilepsy #ILAE International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Collagen mutations may increase the risk for cerebral hemorrhages, yet are not detectable in standard coagulation tests. doi.org/10.1002/epi4.1… #epilepsy #ILAE #coagulopathy #COL4A2 #patient safety #Skruf International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: #Ivermectin reduces seizures in onchocerciasis-associated epilepsy (OAE) via its antiparasitic and anticonvulsant properties. doi.org/10.1002/epi4.1… #epilepsy #ILAE #ASM #GABA #neuroinflammation #onchocerciasisassociatedepilepsy International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Creative cognitive processes produce novel thoughts that translate to useful products or concepts, expressed in better adaptation. doi.org/10.1002/epi4.1… #epilepsy #ILAE #defaultmodenetwork #eloquentmusic #neurobiology #seizures International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Everolimus treatment for 12 weeks did not show overall superiority in reducing seizures compared to placebo. doi.org/10.1002/epi4.1… #epilepsy #ILAE #drugresistantepilepsy #Everolimus #focalcorticaldysplasia #MTORinhibitors International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Epilepsia Open - Recently published articles (December 8, 2024) mailchi.mp/ilae/epilepsia… #epilepsy #ILAE International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Scalp high-frequency oscillation (#HFO) was seen more commonly and with a significantly higher detection rate in patients with poor seizure control. doi.org/10.1002/epi4.1… #epilepsy #ILAE #ASM #pediatric #ripple #spike International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Myo-inositol, scyllo-inositol and D-Chiro-inositol interact with several protein targets involved in different biological pathways. doi.org/10.1002/epi4.1… #epilepsy #ILAe #epileptogenesis #inositol #interactingproteins International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Antiseizure medication prescribing in people with Dravet syndrome: An analysis of real-time administrative data doi.org/10.1002/epi4.1… #epilepsy #ILAE #ASM #cannabidiol #Dravetsyndrome #fenfluramine #stiripentol International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: In #GLUT1DS cases resistant to KDT, exploring alternative treatment options is essential for symptom control and maintaining a satisfactory quality of life. doi.org/10.1002/epi4.1… #epilepsy #ILAE #drugresistant #ketogenicdiet International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: MRI anomalies in patients with PNES are common, including lesions typically linked to epilepsy. doi.org/10.1002/epi4.1… #epilepsy #ILAE #dissociation #MRI #neuroimaging #PNES International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Epilepsy affects 60% of patients with creatine transporter deficiency (CRTR-D). doi.org/10.1002/epi4.1… #epilepsy #ILAE #cannabinoidtherapy #creatinedeficiency #developmentalencephalopathy #precisionmedicine #cannabidiol #clobazam International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Infants with NE who experience ENS have a higher rate of later epilepsy in comparison to those who do not. doi.org/10.1002/epi4.1… #epilepsy #ILAE #EEG #neonatal #encephalopathy #seizures International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: Gut-microbiota-brain axis (GMBA) is affected by traumatic brain injury (TBI). doi.org/10.1002/epi4.1… #epilepsy #ILAE #endotoxemia #intestinalbarrier #kindling #microbiome #microbiotatransplant #traumaticbraininjury #TBI International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: As a marker of left hippocampal integrity, verbal PAL exhibits comparable clinical properties to the Rey Auditory Verbal Learning Task (RAVLT). doi.org/10.1002/epi4.1… #epilepsy #ILAE #verbalmemory #Weschlermemoryscale International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Epilepsia Open - Recently published articles (December 22, 2024) mailchi.mp/ilae/epilepsia… #epilepsy #ILAE International League Against Epilepsy Wiley Neuro @Epilepsiaopen

Key point: C-NORSE is a neurological emergency but the therapeutic window is still unclear. doi.org/10.1002/epi4.1… #epilepsy #ILAE #autoantibodies #brain #MRI #immunotherapy #NORSE International League Against Epilepsy Wiley Neuro Epilepsia Open

Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches doi.org/10.1002/epi4.1… #epilepsy #antiseizuremedications #developmentalandepilepticencephalopathy #algorithmupdate International League Against Epilepsy Wiley Neuro @Epilepsiaopen