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.Erez Tzvi Yirmiya (Weizmann Institute, Israel) et al analyzed groups of related Bacillus #phages that showed sensitivity to bacterial defense systems, & discovered 4 distinct families of anti-defense proteins that inhibit the Gabija, Thoeris, & Hachiman systems buff.ly/46pdiv3

Amazing discovery of Acb2 as the FIRST "super sponge" that sequesters multiple immune signals 🤩 Congrats!

Phages produce NAD+ to reverse the outcome of multiple defense systems! 🤩

Congrats Tana! Having you as a friend and colleague in the lab was spectacular. so glad you are not moving far! Can't wait to hear about your future science 🤩

My friend François Rousset is opening his lab in Lyon. Can't wait for the exciting science that will come out of your lab!

Thrilled to announce the Rothschild Symposium on phage-bacteria interactions in honor of Sorek Lab! Join us for inspiring talks by Aude Bernheim, Alan R Davidson, Avigdor Eldar, and @BejaLab. Plus, we're awarding 3 PhD prizes for exceptional research in the field. Don't miss it!🤩

We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & Ilya Osterman

I'm excited to see the published version of this amazing work. Erez Tzvi Yirmiya et al identified viral proteins that inhibit host immunity using structural predictions of protein-protein interactions. Congrats to you all Sorek Lab & Kranzuch lab! 🥂

Check out our paper using protein structures to uncover immune inhibitors hidden among millions of phage genes! These inhibitors block immune proteins from bacteria, plants and even humans, showing how immunity and counter-immunity mechanisms are conserved across kingdoms! 🦠🌿🧍‍♀️

How did researchers develop a systematic method to discover viral proteins that can inhibit immune responses across different domains of life? Weizmann Institute Cell "Structure-guided discovery of viral proteins that inhibit host immunity" • A new pipeline was