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George Carlin was right about golf.

❌ FALSE: “For 20 years…we were directing Alzheimer’s research to one hypothesis. And any other hypotheses were shut down.” - Sec. Kennedy Over the last decade, less than 14% of new National Institutes of Health (NIH) Alzheimer’s projects focused on amyloid beta as the

Delighted to see not one, not two, but three papers about astrocytes in Science today! Here's our contribution to that collection. Come follow us on bluesky! Papouin lab twitter/X: over & out... science.org/doi/10.1126/sc…

A new microglia replacement protocol based on three cycles of a CSF1R inhibitor can treat neurological disorders in mice while avoiding the need for arduous preconditioning, pointing to a safer alternative to bone marrow transplantation. Read more in Science Translational Medicine:

Happening today at 1pm!

Studies in mice reveal that AMPK activation mediates the effects of GLP-1RAs on AD, highlighting the therapeutic potential of GLP-1RAs for the treatment of #Alzheimers disease Nature Aging nature.com/articles/s4358…

Happening now in Holden!

Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau: Neuron cell.com/neuron/fulltex…

Excited to share our latest paper in Molecular Metabolism: IL-6 integrates sex- and diet-dependent circadian and metabolic regulation. Grateful to the team and collaborators! #Chronobiology #Metabolism #MolecularMetabolism sciencedirect.com/science/articl…

Congratulations to Dr. Collin Nadarajah (Collin Nadarajah) who successfully defended his PhD thesis yesterday! A job well done, and great things ahead as he returns to med school. WashU DBBS WashUMSTP

A pill for sleep apnea that keeps the airway open Science Magazine Meredith Wadman science.org/content/articl…

GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration: Neuron cell.com/neuron/fulltex…

Video of my goal and a few near-misses from our Scott Gallagher Soccer Club spring team game vs. Lou Fusz Soccer Club, plus two goals from our scrimmage against our boys ECNL 2011 team. I'm #21 in black. James Armstrong Drago Ćeranić Kelly Madsen ECNL/GA/Recruiting/College Soccer College Soccer Truth ™ Auburn Soccer

Ashish Sharma, PhD, a BrightFocus Alzheimer's Disease Research grant recipient, is uncovering the connection between circadian rhythm disruptions and the accumulation of amyloid plaques and tau protein in the brain—two key Alzheimer's biomarkers. This research is deeply personal

I’m truly grateful to the BrightFocus Foundation Foundation for recognizing our research and supporting this journey. It’s an honor to be part of a community driving real progress together. Sincere thanks to Erik Musiek for his invaluable guidance throughout.

Lemborexant, a dual orexin receptor antagonist, ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy nature.com/articles/s4159…

🧠💤 Can better sleep protect the brain? New research from WashU shows that the sleep aid lemborexant improves rest and reduces harmful tau protein buildup—offering potential protection against Alzheimer’s disease. bit.ly/4jubE1Z

This is really exciting and translationally-important work from David Holtzman lab and Samira Parhizkar! WashU Medicine Neurology Center On Biological Rhythms And Sleep

A week ago, I defended my PhD thesis about the role of REV-ERBs in astrocytes in neurodegeneration. None of this was possible without the support of my family, my PI, my wonderful lab and my friends. Now onwards into clinic #PhDone #mstp #washumed

An antibody directed to the NAD-degrading enzyme CD38 in mice restores metabolic fitness, improves cognitive performance & lowers neuroinflammation nature.com/articles/s4146…