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Plasma P-tau, in combination with clinical measures, improves prediction of individual risk of progressing to #alzheimerdisease dementia in independent, multi-center cohorts. nature.com/articles/s4159… Oskar Hansson BioFINDER Sebastian Palmqvist

Very happy to share our new work out today in Alzheimer's & Dementia, showing that BIN1 accelerates amyloid-associated tau accumulation, thereby driving cognitive decline. Many thanks to Michael Ewers, RikOssenkoppele, Oskar Hansson and many others! cutt.ly/gngVS3A

👉🏽 Clearly one of the highlights of AD/PD - Advances in Science & Therapy : a potential PET tracer for aggregated alfa-synuclein for Multiple System Atrophy by Oskar Hansson 👌🏾 #ADPD2022

Researcher Presents First Non-Invasive Images of Alpha-Synuclein in the Brain ow.ly/b2SB50IlPKh RSNA American College of Radiology ACR RFS ACR YPS The American Society of Neuroradiology Journal of Neuroradiology NeurologyLive® OHSU Neuroradiology @USCneurorads Oskar Hansson Lund University ARRS

The BioFINDER is proud to present our latest paper by RikOssenkoppele, @alexa_pichetb et al. published in Nature Medicine today! Link (open access): go.nature.com/3A3WRqX Thread below 👇

New paper in Brain by PhD student Anika Wuestefeld on age-related tau-PET, investigating Aβ-independence and its downstream effects. We validated the results postmortem (thanks to Rush Alzheimer's Disease Center) and included RO948 autoradiography of a PART case doi.org/10.1093/brain/…

Young & Vogel et al. run a computer algorithm on samples of human brain tissue to map how TDP-43 spreads through the brain. The algorithm can identify TDP-43 patterns associated with different dementias, and determine how far the disease has advanced. bit.ly/3I9ywE3

Tau PET has an added clinical value to increase diagnostic certainty, especially in amyloid-β positive patients where Alzheimer disease is a differential diagnosis. ja.ma/3okNFM9 BioFINDER Ruben Smith Oskar Hansson

A new Swedish BioFINDER study addressing the clinical utility of tau-PET in symptomatic individuals published in JAMA Neurology jamanetwork.com/journals/jaman… BioFINDER Oskar Hansson JAMA Neurology Ruben Smith

We report a significant change in diagnoses and medication of patients when tau-PET is added to an already extensive diagnostic work-up including CSF AD biomarkers. Tau-PET further led to a significant increase in certainty of underlying etiology. BioFINDER

🚨Published today in Nature Medicine in conjunction with the presentation at #AAIC23 (4:15, Hall 2) we show the important clinical effects of Lewy body pathology in cognitively unimpaired (nature.com/articles/s4159…) and cognitively impaired individuals (nature.com/articles/s4159…).

New research from Ruben Smith Oskar Hansson & colleagues demonstrates how the α-synuclein PET tracer [18F] ACI-12589 being developed by AC Immune distinguishes multiple system atrophy from other neurodegenerative conditions (including #Parkinsons) nature.com/articles/s4146…

🚨Publication in JAMA 🚨 Blood biomarkers to detect Alzheimer’s disease in primary and secondary care, published today in JAMA led by Sebastian Palmqvist: jamanetwork.com/journals/jama/…

It was one of the best dissertations I have ever visited! Anna really excelled! In the end, I did actually shed a tear because I was so proud of her. I hope she will continue to work with research besides being a fantastic neurologist!

🚨New publication led by Lyduine Collij ‼️ Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease” shows the exacerbating effects of a-synuclein co-pathology in Alzheimer's disease. Now published in Nature Communications ! nature.com/articles/s4146…

🚨New publication led by Anika Wuestefeld published in Alzheimer’s Research & Therapy We find that medial temporal lobe atrophy patterns in *amnestic* early-onset Alzheimer's disease are similar to those of amnestic late-onset AD and show similar levels of co-pathologies. alzres.biomedcentral.com/articles/10.11…

🚨New paper led by Tove Freiburghaus and Daria Pawlik published in Acta Neuropathologica [18F]flortaucipir PET SUVR linearly reflects tau pathology burden and does not bind substantially to tau neurites in neuritic plaques, to TDP-43 or to PART. link.springer.com/article/10.100…

What are the key milestones in Alzheimer’s disease research? In the article "The History of Alzheimer’s Disease," the editors of Nature journals share their insights on this topic. The BioFINDER team is particularly proud to have contributed to a significant milestone in 2020.

🧠Exciting new findings from a great collaboration between the BioFINDER study and the talented Caly Yu Xiao (肖燏) from Jake Vogel group!! In their preprint, they show that tau presence and tau load are guided by unique brain mechanisms. Dive into the details here 👇

‼️New preprint! We are happy to share our latest work led by Toomas Erik Anijärv 🇪🇪 investigating why tau pathology in Alzheimer’s disease (AD) often accumulates more in one hemisphere of the brain than the other. Check out🔗biorxiv.org/content/10.110… or dive into the details below👇