🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

🐭 Can mitochondrial DNA mutations track lineage in murine cancer models❓ Together w/ Elisa ten Hacken plus the mtDNA experts LeifLudwig and Caleb Lareau we investigated this question with mtscATAC-seq using Elisa's #CLL and #RS models. Out now in Cancer Research./1 aacrjournals.org/cancerres/arti…

Elisa ten Hacken has developed a new model for Richter's syndrome, the transition of #CLL to a high-grade lymphoma, which is the perfect context to study clonal evolution using #mtDNA mutations. Check out her brand new Blood Cancer Discovery paper also released today! /4 aacrjournals.org/bloodcancerdis…

Finally, we also saw mtDNA mutations that were further enriched in the Richter's model after transplant into a recipient animal. This demonstrates that - like in human - mitochondrial DNA mutations in mice can be dynamic markers of distinct subclones and differential chromatin./9

1/Very excited to see this out online at Blood Cancer Discovery! Check out our novel mouse models reflective of chronic lymphocytic leukemia (CLL) transformation into Richter’s syndrome achieved via combinatorial CRISPR-Cas9 gene editing! aacrjournals.org/bloodcancerdis…

In vivo modeling of #CLL transformation to #Richtersyndrome reveals convergent evolutionary paths and therapeutic vulnerabilities, by Elisa ten Hacken et al. bit.ly/3uxoFRe Dana-Farber News Dana-Farber Harvard Medical School #chroniclymphocyticleukemia

This was all only possible because of the study’s lead investigator and my incredible mentor Matthew Davids, MD, MMSc. Many, many thanks to him for the generous opportunity to present these results yesterday! #ASH22 Dana-Farber Dana-Farber News

During an early morning session here at #ASH22, there’s an overflow crowd for Dana-Farber Caron Jacobson’s, MD, MMSc, presentation on her findings from her investigator-initiated study of CAR T-cell therapy for CNS lymphoma. There’s not an empty seat in the ballroom.

The story behind Venetoclax, a new cancer therapy, started nearly 40 years ago. How it went from the discovery of a protein to a game-changing cancer drug is a story of persistence and momentum and the first episode of season two of the Unraveled podcast. podcasts.apple.com/us/podcast/unr…

Congrats Elisa!

⁦Inhye Ahn, MD⁩ from ⁦Dana-Farber⁩ presenting at #iwcll2023 on one of the largest datasets ever reported for BTKi resistance mechanisms in CLL ⁦⁦iwCLL⁩

Congratulations to Dr. Susan O’Brien (UCI Health) and Dr. Catherine Wu (@DanaFaber), recipients of the iwCLL Binet-Rai Medals for outstanding contributions to CLL research at #iwCLL2023

Had a great time at #iwCLL2023 sharing our work Romain Guieze Leshchiner Lab Gad Getz Laboratory Stilgenbauer and Wu in an amazing genomics session! Fascinating talks by Cindy Hahn Ferran Nadeu Pauline Robbe

#ASH23 - Abstract 223 Outstanding presentation by Katie Maurer 👏🏻👏🏻👏🏻 Response to axi-cel is associated with: ✅The presence of > 0.5% circulating B-cells at baseline ✅Higher ALC/AMC at baseline ✅Enrichment of clonally expanded CD8+ TEM cells in IP #CARTcell

At #ASH23, Reid Merryman, MD Dana-Farber reveals results from a pilot study that uses circulating tumor DNA to reliably predict relapse in patients with diffuse large B-cell lymphoma (#DLBCL). Press release: ms.spr.ly/6013iTO1S

#ASH23 is about running from a meeting in the Marriot all the way to room 28 in the conference center to see Becky Zon, MD rock her presentation on CHIP and VTE in the UKBiobank

🔬Are you an early-career researcher ready to take the next step in your research career? Apply for ASH & European Hematology Association's #TRTH program! Read the testimonials to see what past participants had to say about their experiences! Apply by June 20: ow.ly/GoW250RJTko #hematology

#AACRlymph24 cochair Ari M. Melnick, Sandrine Roulland, and Erin M. Parry discussed "Lymphoma Clonal Precursors and Transformation" in a plenary session at the Fourth AACR International Meeting on Advances in Malignant Lymphoma. Melnick Lab @SRoulland Erin Parry, MD PhD

Excited to share our latest publication from the Lili Wang lab! by Prajish Iyer et al.🌟 MGA deletion drives Richter’s transformation by modulating mitochondrial OXPHOS, highlighting new therapeutic avenues. Danilov Lab CLL Society Inc. science.org/doi/10.1126/sc…

Happy to share the results of our first #richter trial now published Nature Communications rdcu.be/dQued