🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…

🧵1/ T cells have deservedly been in the🔦for #cancer #immunotherapy, but other engineered cell therapies are now📈. What mediates NK cell exhaustion remains an important unanswered❓. 📄Link: nature.com/articles/s4158… I’m so thrilled🥳to share our work out now🚨nature

Important findings on overcoming dysfunction in engineered NK cells. Congrats!

Incredible advocacy from Parker Institute for Cancer Immunotherapy investigators Crystal Mackall (Stanford Medicine) and Carl June (Penn Medicine) at the FDA Cell & Gene Therapy Roundtable—fighting for kids with cancer. Grateful to HHS.gov for bringing the full team to tackle regulatory, funding, and payor

12/ Bioinformatics isn’t about blindly analyzing big matrices. It’s about asking: “What’s the signal? What’s the noise? And what can I ignore to see the truth?” That’s the real art of dimension reduction.

We are looking for talented postdocs/visiting students to join our team MIT Dept of BE and Koch Institute at MIT to innovate spatial multi-omics technologies, map clinical samples, and integrate AI/ML models to advance next-generation cancer immunotherapy. Please help to spread!!

We previously showed that IFNg is required for CAR-T efficacy in solid tumors, but is it always good? Here, we show that IFNg limits CD28 CAR-T cells and that protection from this signal drives greater antitumor activity and durability. Enjoy! science.org/doi/10.1126/sc…

We’ve been talking about CAR T day for a few weeks now… and you still haven’t registered? Let’s shine a light on some of the exceptional speakers joining us to share their groundbreaking work and insights. This is the first in a 6-part series 🎯 🎙️ Meet: ➡️ Justin Eyquem (San

This is wild. Unclear mechanistically how it might happen, but this provocative study showed that cancer-associated neurons transfer mitochondria to the cancer cell to induce metabolic reprogramming and increase metastasis. Dr. G Ayala Simon Grelet nature rdcu.be/etpZ6

Great opportunity and a great city!

Exciting work from the Beavis and Darcy labs using endogenous promoters to drive tumor-restricted CAR T responses. Congrats A/Prof Paul Beavis and team!

My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15

The T cell subsetting challenge dlvr.it/TLrRl9

🚨Today, in Nature Cancer, we show that CAR-T cells and CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS circuit enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy Memorial Sloan Kettering Cancer Center Parker Institute for Cancer Immunotherapy MSK Department of Medicine

Review JCI insight Enhancing the potency of CAR-T cells against solid tumors through transcription factor engineering insight.jci.org/articles/view/…

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in nature! 🧵below nature.com/articles/s4158…

BREAKING: We uncovered a potent immune alliance that could change how we treat solid tumors. Published in Cancer Cell , we show that Th17 cells *must* work with B cells to eliminate tumors—and keep it from coming back. 📄 cell.com/cancer-cell/fu… 🧵1/12👇Let’s walk through it:

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥

Our manuscript using single cell RNA sequencing to compare two CD19 CAR T cell products, axi-cel and tisa-cel is online at JITC! Frederick L. Locke Moffitt Cancer Center jitc.bmj.com/content/13/7/e… . Our findings (thread):

A glimmer of hope! “To the scientists wondering if there will even be an NIH by the end of this administration: This committee’s resounding message is ‘yes,’” she said. “Congress has your back…” science.org/content/articl…