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Let the #StemCellfie voting begin! 🗳️ Spread the word to your friends, family, and labmates—vote by May 2 for a chance to win prizes, including a magnetic puzzle featuring your submission: bit.ly/44zsJ6z

New in Nature Reviews Bioengineering! 💡 Scientists with Dora Rogkoti, Hannah Donnelly, Matt Dalby, and Manuel Salmeron explore the structure–function relationship of the bone marrow, emphasizing its complex mechanical behavior. 📖 go.nature.com/3YoTPtv

This study out of IIT Bombay illustrates how amylin incorporation in islet matrices through amylin–Col interactions drives #Type2Diabetes progression by impacting β-cell viability and insulin secretion. 🔬 🔗 bit.ly/4iDfF3t | J. Am. Chem. Soc.

Check out this new #review in Trends in Cancer! 📖 Drs. Anna-Marie Finger, PhD, Valerie Marie Weaver, and co-authors discuss the role of the #ECM in driving cancer aggression through its impact on tumor heterogeneity. 🔓 bit.ly/4jMAcny

🔎 Drs. Mohassel and Bönnemann led this new Journal of Clinical Investigation study out of Johns Hopkins Medicine! They propose a new mechanism for the pathogenesis of collagen VI–related disorders that links #ECM regulation of TGF-β with skeletal muscle abnormalities. 👉 bit.ly/4d33Q5x

New research establishes FAP+ CAF-derived FN1 as a critical orchestrator of tumor immunosuppression and identifies the FN1-integrin α5β1 axis as a promising therapeutic target in #BreastCancer. 🎯 🔎 Find out more: go.nature.com/44qhLR4

The latest work out of Weizmann Institute, led by Dr. Orly Reiner and collaborators reports that LIS1 plays a critical role in #ECM regulation during brain #organoid development. 🧠 👀 Find the study in Nature Communications | go.nature.com/3EPnHsr

Scientists introduced a strategy for synthesizing vinyl-functionalized #hydrogel microparticles. The versatility of this platform was demonstrated by the creation of full-thickness engineered skin tissues that support keratinocyte differentiation 💡 bit.ly/4k8hk2c

A non-healing #diabetic infected wound model was used to explore #ECM organization, tensile strength, and metabolomic profiles at a 21-day endpoint as a marker for maturation and improved functionality of repaired tissues over normal scar formation. 💡 bit.ly/43iejXz

Findings from this Nature Communications study unravel the roles of matrix viscoelasticity in #epigenetic regulation and cell reprogramming, with implications for designing smart materials for cell fate engineering. ⛏️ Dig in: go.nature.com/43mkycN

🧫 Drs. Rachel Biggs (Rachel Biggs) and Amy Bradshaw at Medical University of South Carolina (MUSC) summarize recent advances in uncovering critical #fibroblast activation states, ECM organization, and composition of fibrotic ECM, including basement membrane components. AJP-Cell Physiology | bit.ly/3F0kXbK

📖 Drs. Ningthoujam Sonia, Snigdha Saikia, and Anil Mukund Limaye at IIT Guwahati provide a round-up of the prominent literature that presents estrogenic control of matrix #metalloproteinases! You don't want to miss this!👉 bit.ly/4j0oJj2

🧫 Researchers demonstrated that ECM stiffness is significantly higher in endometrial cancer tissues compared to normal endometrium, correlating with elevated expression of ROCK1, a mechanosensitive kinase. CDD press | go.nature.com/3YL7Hyt

🧪 Investigators intervened in cartilage regeneration in vitro using an activator and inhibitor of lysyl oxidase (LOX), thereby evaluating the quality and mechanical properties of tissue-engineered cartilage. Scientific Reports | go.nature.com/4kFeQcb

🧫 This study introduces a novel engineered silk matrix as an advanced solution for soft tissue regeneration, specifically in breast reconstruction surgery. 🔗 bit.ly/3FjvRt7

Dr. Min Lin and collaborators at Xi’an Jiaotong University develop an integrative mechanobiological model to investigate how estrogen modulates stiffness-mediated fibrotic progression. 🤩 Check it out: bit.ly/43pFJJS | Biophysical Journal

This new study out of Sun Yat-sen University Cancer Center reveals that MMP1 expression is elevated in various tumor types and is strongly correlated with metastatic potential. Learn about the impact of MMP1+ subsets on tumor-immune interactions. 👇 go.nature.com/4k5LTWJ

Researchers alongside Dr. Youhua Liu at Southern Medical University showed that matrix metalloproteinase-10 promotes kidney fibrosis by trans-activating β-catenin via EGFR signaling. 🚦 📝: go.nature.com/44Lgnsn

Scientists from the Fabricio Loayza Puch introduce Dual Ribosome Profiling (DualRP) to simultaneously monitor translation and ribosome stalling in multiple tumor cell populations. Learn more about DualRP in their Nature Communications study! 👇 🔗 go.nature.com/43Fg69j