🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

New paper from my group rdcu.be/eoaRr "Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme" in Nature Chemistry — great collaboration with attwaterlab.uk.

A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-s… Jason Buenrostro Fei Chen Lab Ajay Labade Caroline Comenho zack chiang Science Magazine

Njardarson Lab (my alma matre) has released the Top 200 Drugs of 2024! Once again biologics continue to grow in their domination. Free high res download below. bpb-us-e2.wpmucdn.com/sites.arizona.…

🚨 New paper alert! 🚨 Can we simultaneously achieve deep, high-res, large field-of-view imaging without the usual trade-offs? 🤔 🧬🔬 YES: #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC_OPR)! #SuperResolution 📄 nature.com/articles/s4146… Nature Communications 🧵👇

After a multi-year journey to bring thianthrenation-like chemistry to water, we now present a selenoxide reagent that can be used to perform single atom modifications selectively on tyrosine residues in proteins or peptides! Out now in Nature Chemistry! nature.com/articles/s4155…

Using mBaoJin derivative, Peng Zou lab engineered highly photostable green eFRET GEVI, named Vega, exhibits more than 20-fold slower photobleaching than Ace-mNeon2, and allows for long-term voltage imaging in brain slice and in vivo in mice biorxiv.org/content/10.110…

Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… Eric Betzig Legant lab

Thanks again to Hannes Stärk for hosting us on his reading group yesterday to talk about Boltz-2 and for the more than 450 people who joined! For everyone who missed it, you can find here the recording: youtu.be/iHDauMATkr0?si…

🚫 No dyes. No bleaching. 🔬 Just AI + label-free microscopy = vivid virtually stained images New in Nature Machine Intelligence: A deep learning model that enables robust virtual staining across microscopes, cell types & conditions. #CZBiohubSF Shalin Mehta explains:

🧫🔬I am looking for a PhD student in cell biology to study the endoplasmic reticulum and mitochondria using advanced imaging techniques, including super-resolution microscopy. jobvector.de/job/biochemike… More positions (PhD, assistant, postdoc) will be available soon!

We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇

Meet the speakers of our anniversary symposium "Advances in Structural Analysis of Biomolecules: From Subcellular Imaging to Drug Design" cbc-cpc2025.org October 23-24, 2025, Berlin Please like and share! #ChemBioPhys2025

Temporal domain multiplexing enables multiplexed imaging in a single channel with spectrally similar FPs using per-pixel unmixing based on differences in photobleaching rates. To facilitate this approach, we developed new far-red FPs biorxiv.org/content/10.110…

🔬👨‍💻📰 #SReD is out! Automated structural detection for #ImageJ & #FIJI, from nano to macro ✨🐘. No training data, no bias - texture analysis with GPU acceleration!⚡️ Brainchild of Afonso Mendes and adventure w Christophe Leterrier lab + friends. Check: nature.com/articles/s4146…

A new and simple model-free method to analyze smFRET experiments. Protein dynamics from nano- to milliseconds without the nasty diffusion decays in standard FCS experiments - kudos to the great Ivan Terterov! Have a look! nature.com/articles/s4146…

It's here! ✨ The #ExSRRF protocol paper is out 😍. Full details for merging Expansion Microscopy with eSRRF analysis. From cells to tissue. A partnership with Victor Puelles. Lead by Dominik Kylies and Hannah Heil + colleagues. #ExM #eSRRF ➡️ Open link: rdcu.be/euvEw

BioEmu now published in Science Magazine !! What is BioEmu? Check out this video: youtu.be/LStKhWcL0VE?si…

Ready for super-G4s? We identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells. These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf

Inspired by nature, chemists have spent the last 50 years systematically designing and synthesizing a vast array of sugar modified nucleic acids, so-called xenonucleic acids (XNAs). Check out this NAR review on the XNA alphabet! academic.oup.com/nar/article/53…

AI is transforming research in the life sciences, but access remains limited. 🦒AI4Life Team addresses this challenge by providing access to FAIR AI models & AI-ready image-analysis datasets. 🎥Watch their talk from #ImageData Community Days: youtu.be/JWpSbGUqYi8