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1/🚀 Excited to share RegVelo, our new computational model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇 biorxiv.org/content/10.110…

Unraveling the tumor-initiating cells in hepatocellular carcinoma dlvr.it/TGllYz

Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains sciencedirect.com/science/articl…

"Everything in epigenetics is circular". Here, we explore how memory stored locally on chromatin has a crucial role in stabilising cellular state, updating our view of the epigenetic landscape from one shaped by the genotype, to one moulded by experience doi.org/10.1186/s13059…

Cancer statistics in 2025 🇺🇸- new report 🚨 Cancer is becoming a new disease. We're seeing a fundamental shift in who gets cancer, moving from a predominantly male, elderly disease to one that increasingly affects women and younger people. Key highlights 🧵

#Cancer cells spread to #CSF by interacting with the choroid plexus, creating a supportive environment. We discovered they raise #GABA levels in choroid plexus through a specific pathway, and blocking this process can improve treatment for #LMD. USC Brain Tumor Center (uscbtc) @NCICancerBio SNO

Supervised Learning and Unsupervised Learning #infographic — by Data Science Dojo #DataScience #AI #MachineLearning #algorithms #DeepLearning

Precise RNA targeting with CRISPR–Cas13d go.nature.com/4gEn95x

Our February issue is live! 🎉 nature.com/nmeth/volumes/… On the cover, a human brain emerges from multiple stem cell lineages, representing a method to link genetic variation to neurodevelopmental trajectories. Paper here: nature.com/articles/s4159… Image by Philipp Dexheimer.

A tour de force review of the connections between the nervous and immune systems nature nature.com/articles/s4158… Fran Quintana Lab

Despite the trying times, thrilled to share our Nature Protocols piece on massively parallel in vivo Perturb-seq: nature.com/articles/s4159…

Single-cell CRISPR screening in mouse brain nature.com/articles/s4159…

Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus rd.springer.com/article/10.100…

New online! Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis bit.ly/3XC0xvy

Thrilled to share our work Mariella Filbin, @GojoJohannes, and Carl Koschmann, now published in Cancer Cell. We present a translational approach identifying the PDGFRA inhibitor avapritinib as a novel targeted treatment for pHGG with PDGFRA alterations. cell.com/cancer-cell/fu…

Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy dlvr.it/TJWHZk

Let's do CRISPRa without virus and plasmids!!! Congratulations to Tobi and all the authors ! It was a really fun project, revealing some exciting results! academic.oup.com/nar/article/53…

Delighted to share a step-by-step protocol for spatially resolved epigenome-transcriptome co-sequencing to map tissue development, aging & disease. Fully committed to open science!! ⁦SenNet Consortium⁩ ⁦Human BioMolecular Atlas Program (HuBMAP)⁩ ⁦NIH Common Fund⁩ @NCIHTAN nature.com/articles/s4159…

🎉 Congratulations Dr. Bennett, Dr. Levine, Dr. Nobre and the contributing authors on our Nature Cancer publication “A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis” rdcu.be/em0BS

Infrared contact lenses allow people to see in the dark, even with their eyes closed. cell.com/cell/fulltext/… USTC Global Yuqian Ma & colleagues Cell