Short read sequencing

DNA and RNA sequencing methods are rapidly evolving, each with its own benefits and challenges. Find out how the Long-read RNA-Seq Genome Annotation Assessment Project (LRGASP) can help you choose the right long-read sequencing method for your research. nature.com/articles/s4159…

Out today: the Long-read RNA-Seq Genome Annotation Assessment Project (LRGASP) paper, featuring contributions from many GENCODE members, a systematic evaluation of methods for long-read transcript detection and quantification: nature.com/articles/s4159…

I´m thrilled to see our #LRGASP paper published in Nature Methods today. This is the work of many to benchmark long-read methods for transcriptomics, and a must-read paper for those using lrRNA-seq. Special thnks to Francisco Pardo-Palacios and Brooks Lab (1/6) rdcu.be/dJ9ev

We are excited to publish our second-ever Registered Report! The #LRGASP Consortium evaluated various methods for transcript identification and quantification using long-read sequencing technologies. AnaConesa The Sheynkman Lab Brooks Lab Ali Mortazavi nature.com/articles/s4159…

Excited to announce our long-read sequencing methods comparison #LRGASP paper is out! 🎉 It's been a journey since June 2019 at Centre for Genomic Regulation (CRG) where everything started. Huge thanks to all involved. Sílvia Roderic Guigó @julienLag. Can't wait to see its impact! 📊🧬

At long last the #LRGASP project has been published (nature.com/articles/s4159…)! I'm thankful for the amazing group of people I've gotten to work with and learn from during this project, and hope y'all are proud of this great work.

Thrilled to be officially tenured!! 🙌🙌🙌 A huge thanks to the amazing present and past members of the Melé Lab as well as my collaborators who made this possible! BSC-CNS Bioinfo4Women

The landscape of expression and alternative splicing variation across human traits hubs.ly/Q02DxkXK0 Top-read Cell Genomics paper — 14,750 downloads BSC-CNS Marta Melé

My first time in Montreal for #ISMB2024 /HiTSeq 2024 has come to an end. Lots of cool convo and meeting up w new & old friends. That said, I feel like there were some trends …and confusions… as I hear in various talks on long-read RNA-Seq that I want to put out my thoughts on. 🧵/1

Postdoctoral position open in Barcelona!! The Melé Lab is looking for computational biologists interested in large-scale transcriptome data analysis. Check out our website bsc.es/discover-bsc/o… & e-mail me with a CV and a motivation letter before August 31st!

Excited to share our work on alternative splicing (AS) rdcu.be/dSHtu. This version, compared to the biorXiv one, is much more succinct due to word limits; I hope you will have a look. Congrats to @BenjaminFair3 and Carlos Buen Abad for their incredible work!🧵⬇️

Excited to share our paper on multiomic changes in PiD & AD! We uncover cell-type & disease-specific CREs and predict TF occupancy. Explore our interactive database: swaruplab.bio.uci.edu/scROAD Huge thanks to co-first authors Sam Morabito & Sudeshna! biorxiv.org/content/10.110…

Happy to see our comparative study using scATAC + scRNA to study Pick's and Alzheimer's disease out in the world 😍 Was great to work with ZeChuan Shi, Sudeshna Das, and the Swarup Lab swaruplab on this one. biorxiv.org/content/10.110…

So happy for winning the best presentation award at the #ESCS2024 ESCS2024 and thankful for the networking and interesting talks. Looking forward now for #ECCB2024 ECCB2026 Geneva, Switzerland during the rest of the week.

Doing good science is 90% finding a science buddy to constantly talk to about the project.

BigSur: Statistically principled feature selection for single cell transcriptomics biorxiv.org/content/10.110…

Congratulations to my graduate student, Ze, for presenting their exciting research to a packed audience of over 500 at #ASHG24. So proud of your dedication and the impact of your work on advancing our understanding of genomics. Keep shining! #ProudAdvisor #ASHG2024

📢NEW PREPRINT ALERT Thrilled to share our latest work “Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence” (shorturl.at/jpv0S) Maria Sopena Rios Aida Ripoll-Cladellas Marta Melé Does immune aging differ between sexes? Learn more here🧵

I’m so excited to share the work I’ve been part of from the first year of my postdoc at the Melé Lab. We analyze a long-read RNA-seq dataset derived from genetically-diverse samples. To see what we found please read the thread 😁 bsky.app/profile/melela…