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Online Now: Central trained immunity in the context of bladder cancer immunotherapy dlvr.it/TLkhsr

Nature research paper: Whole-genome ancestry of an Old Kingdom Egyptian go.nature.com/45TzvVI

Should #radicalcystectomy ever be considered for consolidate therapy post EV/P?dailynews.ascopubs.org/do/personalizi… Petros Grivas Shilpa Gupta Tom Powles Matt Galsky Oncology Brothers Sumanta K. Pal, MD, FASCO Yüksel Ürün niraj Ashish M. Kamat, MD, MBBS IBCG SWOG Cancer Research Network Society of Urologic Oncology Bladder Cancer Advocacy Network

Did you know that NIH funded the development of 354 out of 356 drugs that were approved from 2010-2019? Only 2 were privately funded. The same NIH with a proposed 40% budget cut. What are we doing to medical innovation? Gift article link below…🎁💉 nytimes.com/interactive/20…

Emerging ‘co-scientist’ systems use chatbots to mimic the deliberations of a research group go.nature.com/3IviKpT

nature.com/articles/d4158…

1/5 How reproducible are phase III oncology trials? 📊 With Alexander Sherry Erik van Zwet Ethan Ludmir MD et al. We analyzed 632 RCTs (~496,000 pts). The data offer both reassurance and caution for clinicians and researchers. pubmed.ncbi.nlm.nih.gov/40628175/ 👇#MsaouelLab

Excellent work Pavlos Msaouel and team!

These plastic particles smaller than a human hair can pass through cell walls and enter the food web go.nature.com/3TxSPjT

Introducing "Here's What We Know,” a series about what science tells us right now for topics like clinical trials and cancer research, highlighting how science improves medical treatments. No jargon. Just clarity. We’re connecting what happens in the lab to your doctor’s office.

Our WCM Englander Institute for Precision Medicine colleague Bhavneet Bhinder will present the nature article, "Development and Validation of an Autonomous #AI Agent for Clinical Decision-making in #Oncology on July 31st, please join us!

MSH6 as a prognostic biomarker in bladder cancer and its correlation with immunity nature.com/articles/s4159…

AI co-scientists excel at summarizing literature. But real scientific discovery comes from interpreting complex raw data and building conceptual models. The next gen of AI partners must learn to do the same. My thoughts on what's next for AI in science: open.substack.com/pub/profelemen…

Can an AI model predict perfectly and still have a terrible world model? What would that even mean? Our new ICML paper formalizes these questions One result tells the story: A transformer trained on 10M solar systems nails planetary orbits. But it botches gravitational laws 🧵

This is a wonderful review in Trends in Cancer on extrachromosomal DNA (ecDNA) from the best in the field, & it’s #OpenAccess. Extrachromosomal DNA: shaping the evolutionary dynamics of cancer cell.com/trends/cancer/… Mischel Lab Charles Swanton Benjamin Werner

An incremental approach risks ceding leadership to global competitors. We believe a decisive, well-resourced national plan can catalyze a new golden era of American-led biomedical discovery and transform human health. Read the full strategy here: drive.google.com/file/d/19fMA-Q… 6/6

Read our WCM Englander Institute for Precision Medicine response to the NIH’s call for a national AI strategy.

Definitely not as cute as the cat force, but still a fun roller coaster ride through a xtal of a novel sequence! Thanks to NimaAI. Prompt: Nima, please make it look cool 😎

Sequential inguinal-LN biopsies in 24 patients with SLE, SSc, RA & IIM reveal that a single infusion of CD19-CAR-T cells eradicates intranodal CD19/20⁺ B cells (0 cells mm-² in all 12 cases) and collapses germinal-centre architecture (FDC-, TFH- & Ki-67-negative). By contrast,

Monster black hole merger is biggest ever seen nature.com/articles/d4158…