🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

I wrote a blog post on the academic job market. This is mostly to share my own materials like research/teaching statements, chalk talk slides, startup budgets, etc. But along the way I also give my best notes. Hope it helps some of y'all out there! tinyurl.com/wnrasp9v

Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/

👏New in #JEV👏Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α. Authors from Shanghai Jiao Tong University demonstrate a new regulatory mechanism between lysosomal homeostasis and EV secretion. 📖👉 bit.ly/3YuAoNr

Check out our latest study about glioma stem cells promote radioresistance by transferring the metabolic enzyme NAMPT to radiosensitive cells through microvesicles.

LOV-Turbo is published today in Nature Methods and plasmids for LOV-Turbo are available on Addgene, here: addgene.org/browse/article… We hope many people will use LOV-Turbo in exciting new ways! nature.com/articles/s4159… If you plan to use NanoLuc BRET to activate LOV-Turbo, please

Large database of POSTDOC fellowships in cancer research and oncology. 50 fellowships; each entry has description, deadline, amount, eligibility criteria. Download this database here: research.jhu.edu/rdt/funding-op…

Online now! A change to #lysosome morphology from vesicular to tubular form supports #lifespan extension upon #dietaryrestriction and promotes heightened #autophagy and healthy #aging in C. elegans @johnsona_lsu LSU College of Science nature.com/articles/s4358…

STING neutralizes the pH of Golgi-derived vesicles through a channel in its transmembrane domain. This function is conserved in at least humans, mice, and frogs. A great collaboration with Dr. Guijun Shang's group. A big thanks to all co-authors for their contributions!

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Deeply sad to hear. Judy’s talk was so insightful. Her legacy and impactful work will always inspire us. RIP.

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome

Fangyu Wang is doing some exciting stuff in the Cerione Lab. Check out her #LabFeatureFriday over on our LikedIn bit.ly/4b48iiw

Check out the latest publication from the Kaelin Lab! Congrats Muhannad 🎉

Check out the group’s recent collaborative project to establish a mouse model of Vhl-deficient clear cell kidney cancer! Great work everyone! pnas.org/doi/10.1073/pn… Eli Van Allen National Cancer Institute and many others!

Another great year coming to a close! Happy Holidays to everyone!

We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the HIF-mediated transcription, expression, and HLA presentation of ERVs in kidney cancer and leveraging them for immunotherapy cell.com/cell/fulltext/…

Study in Cell co-led by Dana-Farber’s William Kaelin, MD, and Catherine Wu, MD, suggests the immune system can mount an attack on cancer cells that, due to cancer-driving mutations, present fragments of endogenous retroviral proteins on their surface. ➡️

New study just out from KaelinLab in Cancer Discovery elucidating more about the dependence of #kidneycancer tumor cells on HIF2, implicating Cyclin D1 activity in resistance mechanisms to HIF2-targeted therapy aacrjournals.org/cancerdiscover…